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The void and the brain.

Christof Koch

Cell Reports July 22, 2025 DOI: 10.1016/j.celrep.2025.116072 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Observational study Peer reviewed
Population Volunteers inhaling a high dose of 5-methoxy-N,N-dimethyltryptamine
Interventions 5-methoxy-N N-dimethyltryptamine
Dose high dose
Topics 5-MeO-DMT Altered states of consciousness
Keywords Psychedelics Hallucinogens Entheogens Psychoactive compounds Brain research Neurobiology Brain activity EEG Neural state Brain function Mind Awareness Consciousness exploration
Citations 1
Key findings The psychedelic 5-methoxy-N,N-dimethyltryptamine slows brain activity profoundly without significantly reducing alpha band power, a pattern atypical of other psychedelics.

Abstract

Blackburne et al. track the electroencephalogram activity of volunteers inhaling a high dose of the powerful psychedelic 5-methoxy-N,N-dimethyltryptamine, revealing profoundly slowed-down brain activity but no significant reduction of alpha band power that is typical of other psychedelics.1.

Comparable studies

Other observational and cohort studies on 5-MeO-DMT, most cited first.

Study Year Design Participants
A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms. Volunteers who inhaled vapor from dried toad secretion at several European locations 2019 Observational cohort n = 42
Intensity of Mystical Experiences Occasioned by 5-MeO-DMT and Comparison With a Prior Psilocybin Study Individuals at a psychospiritual retreat in Mexico 2018 Observational cohort n = 20
Neural and subjective effects of inhaled N,N-dimethyltryptamine in natural settings. Healthy and experienced participants 2021 Observational field study n = 35
A Phase 1, Dose-Ranging Study to Assess Safety and Psychoactive Effects of a Vaporized 5-Methoxy-N, N-Dimethyltryptamine Formulation (GH001) in Healthy Volunteers. Healthy volunteers 2021 Prospective dose-finding study n = 22
Open-label study of consecutive ibogaine and 5-MeO-DMT assisted-therapy for trauma-exposed male Special Operations Forces Veterans: prospective data from a clinical program in Mexico. Trauma-exposed Special Operations Forces Veterans 2023 Prospective clinical program evaluation n = 86

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5-MeO-DMT Altered states of consciousness DMT