PLoS One
October 26, 2017
Grace E. Fox, Meng Li, Fang Zhao et al.
Ketamine is known to induce psychotic-like symptoms, including delirium and visual hallucinations. It also causes neuronal damage and cell death in the retrosplenial cortex (RSC), an area that is thought to be a part of high visual cortical pathways and at least partially responsible for ketamine’s psychotomimetic activities. However, the basic physiological properties of RSC cells as well as...
Oxford University Press eBooks
October 26, 2017
Susan Blackmore
112 citations
Consciousness is ‘the last great mystery for science’. How can a physical brain create our experience of the world? What creates our identity? Do we really have free will? Could consciousness itself be an illusion? Exciting new developments in brain science are continuing these debates, and the field has now expanded to include biologists, neuroscientists, psychologists, and philosophers....
Psychological Medicine
October 2, 2017
André Schmidt, Felix Müller, Claudia Lenz et al.
62 citations
Abstract Background Recent evidence shows that the serotonin 2A receptor (5-hydroxytryptamine2A receptor, 5-HT 2A R) is critically involved in the formation of visual hallucinations and cognitive impairments in lysergic acid diethylamide (LSD)-induced states and neuropsychiatric diseases. However, the interaction between 5-HT 2A R activation, cognitive impairments and visual hallucinations is...
Drug and Alcohol Dependence
October 1, 2017
Charles W. Schindler, Benjamin R Gramling, Zuzana Justinova et al.
The misuse of synthetic cannabinoids is a persistent public health concern. Because these drugs target the same cannabinoid receptors as the active ingredient of marijuana, Δ9-tetrahydrocannabinol (THC), we compared the effects of synthetic cannabinoids and THC on body temperature and cardiovascular parameters. Biotelemetry transmitters for the measurement of body temperature or blood pressure...
Journal of Evaluation in Clinical Practice
October 2017
Jorge Gonçalves
Identified as a mental disorder by Emil Kraepelin and Eugen Bleuler (1858-1939), schizophrenia has been subject to various criticisms, on both political and scientific grounds. Still, until the latest edition of the Diagnostic and Statistical Manual of Mental Disorders, DSM-5, as the'Spectrum of Schizophrenia and Other Psychotic Disorders'. In this article, we will assume a neutral conception...
Uniwersyteckie Czasopismo Socjologiczne
September 30, 2017
Konrad Pepłowski
Stanislav Grof jest jednym z twórców psychologii transpersonalnej, obok psychoanalizy, behawioryzmu oraz nurtu humanistycznego stanowiącej „czwartą siłę w psychologii”. Pochodzący z Czech naukowiec zasłynął jednak prawdopodobnie bardziej jako pionier w dziedzinie badań nad wpływem LSD na umysł i terapeutycznym jego zastosowaniem. Poza mózg: narodziny, śmierć i transcendencja w psychoterapii to...
Frontiers in Neuroscience
September 28, 2017
Michael Winkelman
105 citations
Neuropharmacological effects of psychedelics have profound cognitive, emotional, and social effects that inspired the development of cultures and religions worldwide. Findings that psychedelics objectively and reliably produce mystical experiences press the question of the neuropharmacological mechanisms by which these highly significant experiences are produced by exogenous neurotransmitter...
Acta Psychiatrica Scandinavica
September 21, 2017
Felix Müller, Claudia Lenz, Patrick C. Dolder et al.
149 citations
Objective It has been proposed that the thalamocortical system is an important site of action of hallucinogenic drugs and an essential component of the neural correlates of consciousness. Hallucinogenic drugs such as LSD can be used to induce profoundly altered states of consciousness, and it is thus of interest to test the effects of these drugs on this system. Method 100 μg LSD was...
Psychopharmacology
September 16, 2017
Yasmin Schmid, Matthias E. Liechti
234 citations
RATIONALE: Lysergic acid diethylamide (LSD) and other serotonergic hallucinogens can induce profound alterations of consciousness and mystical-type experiences, with reportedly long-lasting effects on subjective well-being and personality. METHODS: We investigated the lasting effects of a single dose of LSD (200 μg) that was administered in a laboratory setting in 16 healthy participants. The...
Frontiers in Psychology
September 1, 2017
Antonio Alcaro, Stefano Carta, Jaak Panksepp
Psychologists usually considered the "Self" as an object of experience appearing when the individual perceives its existence within the conscious field. In accordance with such a view, the self-representing capacity of the human mind has been related to corticolimbic learning processes taking place within individual development. On the other hand, Carl Gustav Jung considered the Self as the...