Nature Communications
June 5, 2023
Ang Li, Haiyang Liu, Xu Lei et al.
Consciousness arises from the spatiotemporal neural dynamics, however, its relationship with neural flexibility and regional specialization remains elusive. We identified a consciousness-related signature marked by shifting spontaneous fluctuations along a unimodal-transmodal cortical axis. This simple signature is sensitive to altered states of consciousness in single individuals, exhibiting...
Clinical Toxicology
June 2, 2023
Leo J. Schep, Robin J Slaughter, Martin Watts et al.
63 citations
INTRODUCTION: Ketamine is a pharmaceutical drug possessing both analgesic and anaesthetic properties. As an anaesthetic, it induces anaesthesia by producing analgesia with a state of altered consciousness while maintaining airway tone, respiratory drive, and hemodynamic stability. At lower doses, it has psychoactive properties and has gained popularity as a recreational drug. OBJECTIVES: To...
World Journal of Clinical Cases
June 1, 2023
Shintaro Shimozawa, Daisuke Usuda, Toru Sasaki et al.
Background: Dextromethorphan is a prevalent antitussive agent that can be easily obtained as an over-the-counter medication. There has been a growing number of reported cases of toxicity in recent years. Generally, there are numerous instances of mild symptoms, with only a limited number of reports of severe cases necessitating intensive care. We presented the case of a female who ingested 111...
International Journal of Psychophysiology
June 1, 2023
Sarah Diezig, Melissa Spaar, Simone Denzer et al.
The ability to organize self-generated thought into coherent, meaningful semantic representations is a central aspect of human cognition and undergoes regular alterations throughout the day. To investigate whether changes in semantic processing might explain the loss of coherence, logic, and voluntary control over thinking typically accompanying the transition to sleep, we recorded N400 evoked...
Journal of Student Research
May 31, 2023
Chandni Kumar, Tom McClelland
Artificial Intelligence (AI) is a method used to teach machines to process and experience data/information the way humans do. The claustrum, the cellular unit of the nervous system that communicates with the body through electrical patterns, is an excellent model for AI when trying to derive consciousness. It has been used as a model for neural networks to teach machines to process, experience,...
Clinical Pharmacology & Therapeutics
May 30, 2023
Pablo Mallaroni, Riccardo Paci, Sabrina Ritscher et al.
34 citations
2,5‐dimethoxy‐4‐bromophenethylamine (2C‐B) is a hallucinogenic phenethylamine derived from mescaline. Observational and preclinical data have suggested it to be capable of producing both subjective and emotional effects on par with other classical psychedelics and entactogens. Whereas it is the most prevalently used novel serotonergic hallucinogen to date, it's acute effects and distinctions...
Progress in Brain Research
May 26, 2023
Helané Wahbeh, Cedric Cannard, Michael Kriegsman et al.
Trance is an altered state of consciousness characterized by alterations in cognition. In general, trance states induce mental silence (i.e., cognitive thought reduction), and mental silence can induce trance states. Conversely, mind-wandering is the mind's propensity to stray its attention away from the task at hand and toward content irrelevant to the current moment, and its main component is...
May 19, 2023
Francesca Ferroni, Edoardo Arcuri, Martina Ardizzi et al.
5 citations
preprint
Perception of one’s self and body in time and space are fundamental aspects of self-consciousness. It scaffolds our subjective experience of being present, in the here and now, a vital condition for our survival and wellbeing. Depersonalisation (DP) is characterized by distressing feeling of being ‘spaced out’, detached from one’s self, body and the world, as well as atypical ‘flat’ time...
ACS Chemical Neuroscience
May 17, 2023
Khalyd J Clay, Ava E Axelrod, Christina M MacLaughlin et al.
2 citations
Several naturally occurring molecules exhibit unique potential in treating certain elements of psychiatric illnesses and are being actively pursued in therapeutic development. Among these are molecules termed entheogens, a preferred name for plant-derived compounds that alter human consciousness for religious or spiritual purposes, which are especially important to various Indigenous groups,...
Frontiers in Neuroscience
May 15, 2023
Stéphane Charpier
14 citations
Clinically, and legally, death is considered a well-defined state of the organism characterized, at least, by a complete and irreversible cessation of brain activities and functions. According to this pragmatic approach, the moment of death is implicitly represented by a discrete event from which all cerebral processes abruptly cease. However, a growing body of experimental and clinical...