Research examining the potential of the psychedelic experience to alter attitudes toward death is steadily emerging. However, the specific mechanisms leading to this change are not well understood. The present study investigated the potential relationship between changes in metaphysical beliefs and changes in death anxiety following a single significant psychedelic experience. A total of 155...
This article explores the relationship between music and rock art by looking at the occurrence of musical instruments at rock art sites in Zimbabwe. Much of the attention paid to the rich rock art heritage of this country has focused on the documentation of sites, the meaning of the painted and engraved motifs in them and the regional variability they display. Despite some brief mentions, the...
Advanced meditation consists of states and stages of practice that unfold with mastery and time. Dynamic functional connectivity (DFC) analysis of fMRI could identify brain states underlying advanced meditation. We conducted an intensive DFC case study of a meditator who completed 27 runs of jhāna advanced absorptive concentration meditation (ACAM-J), concurrently with 7-T fMRI and...
Pathological dissociation is characterized by disruptions in consciousness, memory, identity, perception, and affect, often linked to trauma and observed across various psychiatric conditions. Previous reviews do not fully cover key biological correlates used as biomarkers and do not clearly define the trauma-dissociation link. Therefore, this systematic review gives an overview of the studies...
Archaeological findings witness the anthropological roots of dance, while psychological, medical, cultural and aesthetic studies shed light on health promoting capacities and curative factors inhering in symbolic and expressive body movement. Since dance therapy became a multifaceted discipline in the middle of the 20th century, increasing evidence of beneficial effects has advocated the use of...
The mind-brain problem, which explores the relationship between the mind and brain and the nature of consciousness, remains a scientific challenge. It is not a purely theoretical issue; it profoundly shapes our understanding of human nature. This paper reviews evidence on mind-brain problem views impacting ethical, clinical, and academic domains. Evidence shows that dualism is prevalent, even...
A three-item Peak Experience Scale (PES) was developed to rapidly evaluate the strength of the psychoactive experience, and to guide the dosing regimen, of the psychedelic 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT; mebufotenin). This paper aims to compare the PES with a range of established questionnaires designed to evaluate the psychedelic experience. Data were gathered from three separate...
Dexmedetomidine (DEX) is a well-tolerated sedative drug that induces a sleep-like state. DEX sedation offers a model to study transitions between different states of consciousness (indicated by, eg, behavior, the electroencephalogram (EEG), or transcranial magnetic stimulation (TMS) evoked EEG responses). However, the effects of repeated DEX exposure on recovery are poorly understood and will...
PLoS One2025Anne S. Fleiner, Daniel Kolnier, Nicholas Hagger-Vaughan et al.1 citation
Propofol and ketamine are widely used general anaesthetics, but have different effects on consciousness: propofol gives a deeply unconscious state, with little or no dream reports, whereas vivid dreams are often reported after ketamine anaesthesia. Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist, while propofol is a γ-aminobutyric-acid (GABAA) receptor positive allosteric...
This study aimed to investigate the brain's hemodynamic responses (HRO) and functional connectivity in patients with disorders of consciousness (DoC) in response to acute pressure pain stimulation using near-infrared spectroscopy (NIRS). Patients diagnosed with DoC underwent pressure stimulation while brain activity was measured using NIRS. Changes in oxygenated hemoglobin (HbO) and...