Pharmacology, Biochemistry, and Behavior
September 1, 1997
S. Heishman, K. Arasteh, M. Stitzer
This study compared subjective and behavioral effect profiles of alcohol and smoked marijuana using technology that controlled puffing and inhalation parameters. Male volunteers (n = 5) with histories of moderate alcohol and marijuana use were administered three doses of alcohol (0.25, 0.5, or 1.0 g/kg), three doses of marijuana [4.8, or 16 puffs of 3.55% delta 9-tetrahydrocannabinol (THC)],...
Brain Research
September 1, 1997
Hema Mann, Bruce Ladenheim, Hiroshi Hirata et al.
50 citations
The toxic effects of methamphetamine (METH) (2.5, 5.0 and 10.0 mg/kg) and methylenedioxymethamphetamine (MDMA) (5.0, 10.0 and 20.0 mg/kg) on dopaminergic systems were assessed in the striatum and of the nucleus accumbens in mdr1a wild-type and knockout mice. METH caused significant dose-dependent decreases of dopamine (DA) and DA transporters (DAT) in the striatum and the nucleus accumbens...
Pharmacology, Biochemistry, and Behavior
September 1, 1997
Scott Helsley, David Fiorella, R A Rabin et al.
9 citations
The effects of ibogaine were studied in 12 rats trained to perform in an 8-arm radial maze. In Phase I, the mean number of sessions to criterion and cumulative errors to criterion, as well as mean response rate, were determined for two groups of six animals in a task where only four arms were baited. Group 1 received a potentially neurotoxic dose of ibogaine (50 mg/kg IP administered twice,...
Experimental and Clinical Psychopharmacology
August 1997
R T Burkey, J R Nation
Fourteen male rats were trained to discriminate between injections of 2 mg/kg delta-9-tetrahydrocannabinol (delta 9-THC) and vehicle in a 2-lever operant drug-discrimination paradigm. Following training, substitution tests using a cumulative dosing procedure revealed that anandamide (0.5-16 mg/kg ip), the putative endogenous camabinoid receptor ligand, failed to generalize to the discriminative...
Annals of the New York Academy of Sciences
May 30, 1997
F J Vocci, E D London
6 citations
New technologies utilized for monitoring brain function can be more sensitive in the assessment of desired or undesired pharmacological effects than can clinical examination. Nonetheless, careful case-by-case analysis is required to determine to what extent a change detected with a sensitive imaging modality will have clinical significance. Whereas in some instances the technology may suggest a...
The End of Magic
May 15, 1997
Ariel Glucklich
AbstractWhat is magic? What does magic do? Why do people believe in magic in the face of experience? After living in the Indian city of Banaras and making several trips to tribal areas in Uttar Pradesh, Rajasthan, and Orissa, the author of this chapter discovered a surprising fact: magic is rarely a simple matter of belief. Few magicians and clients in Banaras ever ask themselves why their...
Neuroscience
May 1997
D Kahn, Edward F Pace-Schott, J A Hobson
State-dependent aspects of consciousness are explored with particular attention to waking and dreaming. First, those phenomenological differences between waking and dreaming that have been established through subjective reports are reviewed. These differences are robustly expressed in most aspects of consciousness including perception, attention, memory, emotion, orientation, and thought. Next,...
Human Psychopharmacology: Clinical and Experimental
May 1, 1997
D. Davison, A. C. Parrott
136 citations
Twenty recreational drug users were asked to describe the psychological and physiological effects they experienced under MDMA (3,4-methylenedioxymethamphetamine). The subjects comprised 11 males and nine females, in the age range 18–31 years. Five subjects had taken MDMA once, nine had taken it 2–9 times, while six subjects had taken it +10 times. Each subject completed a modified Profile of...
Drug and Alcohol Dependence
April 14, 1997
A M Cho, Dennis W. Coalson, P A Klock et al.
The purpose of this study was to characterize the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers with different alcohol histories. Subjects were divided into two groups: light drinkers (n = 9) and moderate drinkers (n = 10). A choice procedure was used in which subjects first sampled placebo and a given concentration of nitrous oxide, and then chose...
Pharmacology, Biochemistry, and Behavior
March 1997
Kinzo Matsumoto, Maho Mizowaki, S Thongpraditchote et al.
The alpha2-adrenoceptor agonist clonidine, as well as 5-HT2 receptor antagonists, reportedly suppress 5-HT2 receptor-mediated head-twitch behavior. We investigated the effect of alpha2-adrenoceptor antagonists on the suppressive action of 5-HT2 receptor antagonists in mice pretreated with the noradrenaline toxin 6-hydroxydopamine (6-OHDA) or the 5-HT synthesis inhibitor p-chlorophenylalanine...