Progress in Neuro-Psychopharmacology and Biological Psychiatry
January 10, 2012
Evan J. Kyzar, Christopher Collins, Siddharth Gaikwad et al.
122 citations
Mescaline and phencyclidine (PCP) are potent hallucinogenic agents affecting human and animal behavior. As their psychotropic effects remain poorly understood, further research is necessary to characterize phenotypes they evoke in various animal models. Zebrafish (Danio rerio) are rapidly emerging as a new model organism for neuroscience research. Here, we examine the effects of mescaline...
Buddhist-Christian Studies
2012
Benjamin J. Chicka
Reviewed by: Hidden Dimensions: The Unification of Physics and Consciousness Benjamin J. Chicka Hidden Dimensions: The Unification of Physics and Consciousness. By B. Alan Wallace. New York: Columbia University Press, 2007. xi + 158 pp. The project of B. Alan Wallace will be clear by now to those who have been following his career. He seeks the unification of a Buddhist understanding of...
The American Journal of Drug and Alcohol Abuse
January 2012
Robert S. Goodwin, Michael H Baumann, David A. Gorelick et al.
The endocannabinoid system modulates the hypothalamic-pituitary-adrenal (HPA) axis, but the effect of cannabinoid type 1 (CB1) receptor antagonism following chronic CB1 receptor stimulation in humans is unknown. To evaluate effects of the CB1 receptor antagonist rimonabant on the HPA axis in cannabis-dependent individuals. Fourteen daily cannabis smokers received increasingly frequent 20 mg...
Frontiers in Integrative Neuroscience
2012
Brett Froeliger, Eric L Garland, Leslie A Modlin et al.
Mindfulness meditation involves attending to emotions without cognitive fixation of emotional experience. Over time, this practice is held to promote alterations in trait affectivity and attentional control with resultant effects on well-being and cognition. However, relatively little is known regarding the neural substrates of meditation effects on emotion and cognition. The present study...
Current Medicinal Chemistry
2012
Richard Bergeron, Joseph T Coyle
At central synapses, glutamate is the main excitatory neurotransmitter. Once released from presynaptic terminals, glutamate activates a number of different glutamatergic receptors one of which is the ligand gated ionophore glutamatergic subtype N-methyl-D-aspartate receptors (NMDARs). NMDARs play a crucial role in controlling various determinants of synaptic function. N-acetylaspartylglutamate...
Journal of Pharmacology and Experimental Therapeutics
January 2012
Brett C Ginsburg, David R Schulze, Lenka Hruba et al.
Products containing naphthalen-1-yl-(1-pentylindol-3-yl) methanone (JWH-018) and naphthalen-1-yl-(1-butylindol-3-yl) methanone (JWH-073) are emerging drugs of abuse. Here, the behavioral effects of JWH-018 and JWH-073 were examined in one behavioral assay selective for cannabinoid agonism, rhesus monkeys (n = 4) discriminating Δ⁹-tetrahydrocannabinol (Δ⁹-THC; 0.1 mg/kg i.v.), and another assay...
Current Topics in Medicinal Chemistry
2012
M Walter, Niklaus Denier, M Vogel et al.
Schizophrenia is a major mental illness that is characterized by psychosis, social withdrawal, and cognitive impairment. High comorbidity rates with substance use disorders have consistently been found - especially with abuse of cannabis and psychostimulants. While the role of these drugs in the onset of psychosis and schizophrenia has received much attention, relatively few studies have been...
Libraries and Cultural Resources
2012
Rod Mitchell
Salvia divinorum is a hallucinogenic plant that is used for divination and spiritual communion by the Mazatecs of Mexico. The active component of the plant is salvinorin A, a neoclerodane diterpenoid that selectively acts as a potent κ opioid receptor agonist. Salvinorin A's novel receptor binding profile makes derivatives of the compound potentially useful in the treatment of various...
PLoS One
2012
Anne Klomp, Bjørnar den Hollander, Kora de Bruin et al.
Little is known on the effects of ecstasy (MDMA, a potent 5-HT-releaser and neurotoxin) exposure on brain development in teenagers. The objective of this study was to investigate whether in humans, like previous observations made in animals, the effects of MDMA on the 5-HT system are dependent on age-of-first exposure. 5-HT transporter (SERT) densities in the frontal cortex and midbrain were...
Stress
January 2012
Ye-Ha Jung, Do‐hyung Kang, Min Soo Byun et al.
Meditation may show differential effects on stress and plasma catecholamines based on genetic polymorphisms in brain-derived neurotrophic factor (BDNF) and catechol O-methyl transferase (COMT). Eighty adults (40 men, 40 women; mean age 26 years) who practiced meditation regularly and 57 healthy control adults (35 men, 22 women; mean age 26 years) participated. Plasma catecholamines...