Addiction research published in 2024 (page 6)

The Impact of Mindfulness-Based Stress Reduction Program on Anxiety, Rumination, and Dysfunctional Attitudes in Men Undergoing Drug-Free Addiction Treatment

Journal of Psychological Dynamics in Mood Disorders 2024 Ayatollah Karimi Baghmalek, Foroogh Mahigir, Nastaran Riazi

Objective: The primary objective of this study was to evaluate the effectiveness of the Mindfulness-Based Stress Reduction (MBSR) program on reducing anxiety, rumination, and dysfunctional attitudes in men undergoing drug-free addiction treatment. Methods and Materials: This randomized controlled trial included 30 men undergoing drug-free addiction treatment in Ahvaz city. Participants were...

DOI: 10.61838/kman.pdmd.3.3.7

Mindfulness-oriented recovery enhancement in opioid use disorder: Extended emotional regulation and neural effects and immediate effects of guided meditation in a pilot sample.

Explore 2024 Suchismita Ray, Jamil Bhanji, Nicole R Kennelly et al.

Mindfulness-Oriented Recovery Enhancement (MORE) is an efficacious intervention to aid recovery from substance use disorder. This study in a pilot sample of individuals in treatment for opioid use disorder (OUD) characterizes longer-term changes after the MORE intervention and immediate effects of a brief MORE guided meditation session. Twelve female participants in residential treatment for...

DOI: 10.1016/j.explore.2023.11.001 Full text Mindfulness Opioid use disorder Connectivity Emotion +2

A critical assessment of the abuse, dependence and associated safety risks of naturally occurring and synthetic cannabinoids.

Frontiers in Psychiatry 2024 David J Heal, Jane Gosden, Sharon L. Smith

Various countries and US States have legalized cannabis, and the use of the psychoactive1 and non-psychoactive cannabinoids is steadily increasing. In this review, we have collated evidence from published non-clinical and clinical sources to evaluate the abuse, dependence and associated safety risks of the individual cannabinoids present in cannabis. As context, we also evaluated various...

DOI: 10.3389/fpsyt.2024.1322434 Full text Cannabis Dependence THC - Tetrahydrocannabinol Abuse +2

A scoping review of spirituality in relation to substance use disorders: Psychological, biological, and cultural issues.

Journal of Addictive Diseases 2024 Marc Galanter, William L White, Jag Khalsa et al. 14 citations

Spirituality is a construct encompassing a diversity of strongly held beliefs and pursuits related to life's meaning and purpose. Empirical studies in key domains of spirituality related to substance use disorder (SUD) can be valuable in guiding research, and potentially clinical care. To conduct a scoping review of research on the psychological, biological, and cultural dimensions of...

DOI: 10.1080/10550887.2023.2174785 Full text Addiction Alcoholics anonymous Narcotics anonymous Spirituality +1

Government-funded trial will test psilocybin as treatment for opioid use disorder

Pharmaceutical journal/The pharmaceutical journal 2024

A “UK first” trial will investigate whether psilocybin — the active ingredient in ‘magic mushrooms’ — can help prevent relapse in people recovering from opioid addiction. The psilocybin study, led by researchers at Imperial College London, will involve 28 participants who have recently undergone detoxification from ‘street’ opioids. Participants will receive psilocybin therapy at the […]

DOI: 10.1211/pj.2024.1.335169

Mindfulness-based relapse prevention targeting psychological craving and trait mindfulness in young Chinese women with methamphetamine dependence: a randomized controlled trial.

Frontiers in Psychiatry 2024 Xuan Liu, Yidan Zhang, Hongxin Cheng et al. 3 citations

We recruited 58 MA-dependent young adult females from a compulsory isolation drug rehabilitation center in Sichuan Province and randomly divided them into an MBRP group (n = 29) and a control group (n = 29) according to their degree of psychological craving. The MBRP group received 2 hours of MBRP training twice a week for 4 weeks, alongside routine treatment at the drug rehabilitation center....

DOI: 10.3389/fpsyt.2024.1339517 Full text Ma-dependent Mbrp Female Psychological craving +1

A mindfulness-based intervention for Substance Use Disorder in a Brazilian vulnerable population: a feasibility mixed method study.

Frontiers in Public Health 2024 Mayra Pires Alves Machado, Emérita Sátiro Opaleye, Andre Bedendo et al. 3 citations

Substance Use Disorder (SUD) is a chronic condition that impacts various facets of an individual's life, and society as a whole. The Mindfulness-Based Relapse Prevention (MBRP) protocol is an innovative intervention that can help to prevent relapse, particularly when used as a post-treatment approach. However, although there is significant evidence of its effectiveness in studies from...

DOI: 10.3389/fpubh.2024.1381489 Full text Meditation Mindfulness Substance use disorder Feasibility +4

Three Decades of Research on the Development of Ibogaine Treatment of Substance Use Disorders: A Scientometric Analysis.

Journal of Psychoactive Drugs 2024 Maria Helha Fernandes-Nascimento, André Brooking Negrão, Karine Viana-Ferreira et al. 7 citations

Ibogaine is a natural psychoactive drug that has been investigated for its potential role in the treatment of substance use disorders since the mid-1960s. To evaluate the interest in ibogaine's use as a therapeutic agent, we performed a scientometric analysis covering the last three decades (1993-2002, 2003-2012, and 2013-2022). A complementary analysis was performed to select and describe...

DOI: 10.1080/02791072.2023.2276230 Full text Opioid use disorder Psychedelic therapy Psychedelic-assisted therapy Citespace, psychedelics +24

Ibogaine administration following repeated morphine administration upregulates myelination markers 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNP) and myelin basic protein (MBP) mRNA and protein expression in the internal capsule of Sprague Dawley rats.

Frontiers in Neuroscience 2024 Demi Govender, Leila Moloko, Maria Papathanasopoulos et al. 10 citations

Ibogaine is a psychedelic alkaloid being investigated as a possible treatment for opioid use disorder. Ibogaine has a multi-receptor profile with affinities for mu and kappa opioid as well as NMDA receptors amongst others. Due to the sparsity of research into ibogaine's effects on white matter integrity and given the growing evidence that opioid use disorder is characterized by white matter...

DOI: 10.3389/fnins.2024.1378841 Full text Opioid use disorder Oligodendrocytes Psychedelic medicine ibogaine Psychedelic drug +10

Cannabidiol or ketamine for preventing the impact of adolescent early drug initiation on voluntary ethanol consumption in adulthood.

Frontiers in Pharmacology 2024 Carles Colom-Rocha, Cristian Bis-Humbert, M Julia García-Fuster 3 citations

Few studies have previously evaluated the long-term impact of initiating the combined use of alcohol and cocaine early-in-life during adolescence. Our preclinical study characterized changes in affective-like behavior and/or voluntary ethanol consumption emerging later on in adulthood induced by a prior adolescent drug exposure, as well as tested therapeutical interventions (i.e., cannabidiol...

DOI: 10.3389/fphar.2024.1448170 Full text Alcohol use disorder Addiction risk factors Adolescence Rodent models +7

Decreasing brain activity caused by acute administration of ketamine and alcohol - A randomized, controlled, observer-blinded experimental study.

Frontiers in Pharmacology 2024 Luan Oliveira Ferreira, Esther Padilha da Silveira, Clarissa A Paz et al.

Substance abuse is a major public health problem. In recent years, ketamine, which is a parenteral anesthetic, has been consumed increasingly as an illicit drug together with alcohol, although little is known of how this association alters brain activity. The present study investigated the influence of progressive doses of ketamine, associated with alcohol, on electrophysiological activity. For...

DOI: 10.3389/fphar.2024.1456009 Full text Ketamine Addiction Alcohol-related disorders Brain waves +9

Psychoactive plant derivatives (ayahuasca, ibogaine, kratom) and their application in opioid withdrawal and use disorder - a narrative review.

Journal of Addictive Diseases 2024 Alexandra Arenson, Cynthia I Campbell, Ilan Remler 8 citations

The opioid epidemic and limited access to treatment for opioid withdrawal (OW) and opioid use disorder (OUD) has led individuals to seek alternative treatments. This narrative review aims to educate clinicians on the mechanisms of action, toxicity, and applications of psychoactive plant-based substances patients may be using to self-treat OUD and OW. We specifically discuss ayahuasca, ibogaine,...

DOI: 10.1080/10550887.2023.2195777 Full text Ayahuasca Ibogaine Opioid use disorder Psychedelic therapy +6

IUPHAR-review: The integration of classic psychedelics into current substance use disorder treatment models.

Pharmacological Research 2024 David B. Yaden, Andrea P Berghella, Peter S. Hendricks et al. 12 citations

Substance use disorders (SUDs) have an enormous impact on public health. With classic psychedelic-assisted therapies showing initial promise in treating multiple SUDs, it is possible that these treatments will become legally available options for patients with SUDs in the future. This article highlights how classic psychedelic-assisted therapies might be integrated into current clinical...

DOI: 10.1016/j.phrs.2023.106998 Full text Psilocybin Substance use disorder Psychedelic therapy Medication assisted treatment +5

Ayahuasca for the treatment of alcohol use disorder.

International review of neurobiology 2024 Eduardo A V Marinho, Yasmim A. Serra, Alexandre J. Oliveira-Lima et al. 6 citations

For decades, psychedelics have been investigated for the treatment of psychiatric disorders. Specifically, evidence suggests that psychedelics may have therapeutic potential for the treatment of alcohol use disorder. Several studies with classic psychedelics, including LSD and psilocybin, show promising results, with psychedelics decreasing alcohol drinking and promoting abstinence in...

DOI: 10.1016/bs.irn.2024.07.007 Full text Alcohol use disorder Ayahuasca Rehabilitation Entheogens +6

Studies