Frontiers in Psychiatry
2023
Helena Aicher, Michael J Mueller, Dario Dornbierer et al.
34 citations
There is growing scientific evidence for the therapeutic benefits of the Amazonian plant-based psychedelic "ayahuasca" for neuropsychiatric disorders such as depression and anxiety. However, there are certain challenges when incorporating botanical ayahuasca into biomedical research and clinical therapy environments. Formulations inspired by ayahuasca, which contain specific and standardized...
Frontiers in Psychiatry
2023
Ellen James, David Erritzøe, Tiffanie Benway et al.
16 citations
Due to their potential impact on mood and wellbeing there has been increasing interest in the potential of serotonergic psychedelics such as N,N-dimethyltryptamine (DMT) in the treatment of major depressive disorder (MDD). The aim of Part A of this study was to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) profile of escalating doses of SPL026 (DMT fumarate)...
Emergency Medicine News
December 20, 2022
Stuart Etengoff
FigureFigureThe National Park Service released a warning recently urging visitors not to lick the Sonoran Desert toad (Bufonidae alvarius), also known as the Colorado River toad. (NPS Facebook. Oct. 31, 2022; https://bit.ly/3VItjHH.) Apparently, people have been licking it with abandon in search of a psychedelic high. (NBC. Nov. 7, 2022; https://bit.ly/3B14AX2.) But one need not go to Arizona...
Current Psychiatry
December 1, 2022
Madonna Thakur
3 citations
SAM FALCONERP sychedelics are a class of substances known to produce alterations in consciousness and perception.In the last 2 decades, psychedelic research has garnered increasing attention from scientists, therapists, entrepreneurs, and the public.While many of these compounds remain illegal in the United States and in many parts of the world (Box, 1 page 16), a recent resurrection of...
C&EN Global Enterprise
November 7, 2022
Gina Vitale
Lusaris Therapeutics has launched with $60 million in series A financing to develop therapies for severe neuropsychiatric and neurological conditions. The start-up says the type of compounds it is developing, serotonergic neuroplastogens, are able to induce favorable neural plasticity. Its lead candidate, for treatment-resistant depression, is a formulation of the psychedelic 5-Methoxy- N , N...
Biomolecules
November 2, 2022
Giordano Novak Rossi, Lorena T. L. Guerra, Glen B. Baker et al.
29 citations
Ayahuasca is a psychoactive brew traditionally used in indigenous and religious rituals and ceremonies in South America for its therapeutic, psychedelic, and entheogenic effects. It is usually prepared by lengthy boiling of the leaves of the bush Psychotria viridis and the mashed stalks of the vine Banisteriopsis caapi in water. The former contains the classical psychedelic...
ACS Pharmacology & Translational Science
November 2, 2022
Eline Pottie, Marilyn Naeem, Vamshikrishna Reddy Sammeta et al.
91 citations
4-Phosphoryloxy-N,N-dimethyltryptamine (psilocybin) is a naturally occurring tertiary amine found in many mushroom species. Psilocybin is a prodrug for 4-hydroxy-N,N-dimethyltryptamine (psilocin), which induces psychedelic effects via agonist activity at the serotonin (5-HT) 2A receptor (5-HT2A). Several other 4-position ring-substituted tryptamines are present in psilocybin-containing...
Journal of Psychoactive Drugs
October 11, 2022
Jeremy Weleff, Teddy J. Akiki, Brian S. Barnett
11 citations
Following a decades long period of investigational dormancy, there is renewed interest in employing psychedelics as psychiatric treatments. The academic journals, institutions, and countries that have helped sustain clinical psychedelic research and the evolution of the literature on clinical studies of psychedelics have only recently begun to be investigated. To expand upon this work, we...
Psychopharmacology
October 1, 2022
Daiane Momo Daneluz, Jeferson Machado Batista Sohn, Gabriela O Silveira et al.
To uncover whether psychedelic drugs attenuate fear memory responses would advance the development of better psychedelic-based treatments for posttraumatic stress disorder (PTSD). Ayahuasca (AYA), a psychedelic brew containing indolamine N, N-dimethyltryptamine (DMT) and β-carbolines, facilitates fear extinction and improves neural plasticity. Upon retrieval, fear memory undergoes labilization...
Molecules
September 6, 2022
Joana Gonçalves, Ângelo Luís, Eugenia Gallardo et al.
5 citations
Ayahuasca is an Amazonian drink, which contains β-carboline alkaloids and N,N-dimethyltryptamine. The aim of this study was to evaluate the healing potential of decoctions of a commercial mixture, four individual plants and four mixtures of two plants used in the ayahuasca preparation. Thus, the cytotoxic potential of the samples was evaluated and a wound-healing assay was performed with a NHDF...