Research
2025
Shujie Li, Shu-Jie Li, Qingning Yuan et al.
The 5-HT 1A receptor is a critical target in the treatment of depression and anxiety. Bufotenine derivatives, such as 5-methoxy- N , N -dimethyltryptamine (5-MeO-DMT), 5-hydroxy- N , N -dimethyltryptamine (5-OH-DMT), and 5-hydroxy- N , N , N -dimethyltryptamine—derived from traditional Chinese medicine—have shown antidepressant potential. However, the structural basis of their interaction with...
RevSALUS - Revista Científica da Rede Académica das Ciências da Saúde da Lusofonia
2025
Andreia Machado Brito-Da-Costa, Ricardo Jorge Dinis-Oliveira, Áurea Madureira-Carvalho et al.
Psychedelic compounds, including psilocybin, psilocin, lysergic acid diethylamide (LSD), 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), and mescaline, have long been recognized for their recreational effects and involvement in forensic cases. They have recently gained attention also for their potential therapeutic applications in treating neurological and psychiatric disorders [1]. Despite this...
International review of neurobiology
2025
A M Wingert, Claudio Agnorelli, Joseph Peill et al.
1 citation
Depressive disorders continue to pose a major clinical challenge worldwide, particularly given the high prevalence and increasing number of treatment-resistant cases. Over the past decade, advances in research have elucidated the antidepressant potential of psilocybin and other 5-HT₂A receptor agonists in patients with major depressive disorder (MDD) and treatment-resistant depression (TRD)....
International review of neurobiology
2025
Severin B Vogt, Matthias E. Liechti
1 citation
To design therapeutic trials and select the most appropriate substance and dose for an indication, a detailed understanding of clinical pharmacology is crucial. In recent years, several studies have explored the human pharmacology of different psychedelics and 3,4-methylendioxymethylamphetamin (MDMA). This chapter summarizes pharmacological characteristics of the serotonergic psychedelics...
Frontiers in Psychology
2025
Pascal Michael, David Luke, Oliver Robinson
2 citations
Classical near-death experiences (NDEs) refer to states of disconnected consciousness characterised by a range of features occurring in the context of being close to death. Various psychedelic substances, such as N,N-dimethyltryptamine (DMT), consistently replicate NDE features and may be considered 'near-death-like experiences.' However, a systematic qualitative analysis comparing the...
Thrita
December 31, 2024
Narges Ghasemi Lakeh, Mona Farhadi, Fatemeh Siadat
Background: Acacia species, including Acacia oerfota, are rich in bioactive compounds such as N,N-dimethyltryptamine (DMT), known for its psychoactive properties. Recent studies suggest that low concentrations of DMT may promote neurogenesis and brain plasticity, offering therapeutic potential for neurodegenerative diseases like Alzheimer’s and depression. Methods: A hydroalcoholic extract of...
Functional & integrative genomics
December 30, 2024
Vitor Trinca, Saura R Silva, João V A Almeida et al.
Mimosa tenuiflora, popularly known as "Jurema-Preta", is a perennial tree or shrub native to the tropical regions of the Americas, particularly among Afro-Brazilian and Indigenous Brazilian communities. Known for producing N,N-Dimethyltryptamine, a psychedelic compound with profound psychological effects, Jurema-Preta has been studied for its therapeutic potential in mental health. This study...
Livers
December 27, 2024
Hunter W. Korsmo
Long regarded as illicit substances with no clinical value, N-dimethylated tryptamines—such as N,N-dimethyltryptamine, 5-methoxy-N,N-dimethyltryptamine, and bufotenine—have been found to produce naturally in a wide variety of species, including humans. Known for their psychoactive effects through serotonin receptors (5-HTRs), N-dimethylated tryptamines are currently being reinvestigated...
bioRxiv Preprint Server
December 19, 2024
Evan Lewis-Healey, Carla Pallavicini, Federico Cavanna et al.
1 citation
preprint
N,N-Dimethyltryptamine (DMT) is a fast-acting psychedelic drug that induces a radical reorganisation of conscious contents and brain dynamics. However, our understanding of how brain dynamics support psychedelic-induced conscious states remains unclear. We therefore present a repeated-measures dose-dependent study of the subjective and neural dynamics induced through DMT under naturalistic...
Annals of emergency medicine
December 1, 2024
Mark W Simon, Heather A Olsen, Christopher O Hoyte et al.
12 citations
Psychedelic substances use is increasing in the United States (US). The approval of new psychedelic drugs and legalization of natural psychedelic substances will likely further increase exposures and subsequent adverse events. The study objective is to describe the clinical effects, therapies, and medical outcomes of patients with psychedelic exposures reported to US poison centers. We...