Registered clinical studies investigating psychedelic drugs for psychiatric disorders.
Ashley N. Siegel, Shakila Meshkat, Katie Benitah, Orly Lipsitz, Hartej Gill, Leanna M.W. Lui, Kayla M Teopiz, Roger S McIntyre, Joshua D. Rosenblat
Journal of Psychiatric Research July 1, 2021 DOI: 10.1016/j.jpsychires.2021.05.019 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Sample size | 70 |
| Population | Registered clinical trials on clinicaltrials.gov evaluating psychedelics for psychiatric disorders |
| Topics | Ayahuasca Depression DMT Ibogaine LSD MDMA |
| Keywords | Psychiatric disorders Psychedelic therapy: psychedelics Innovative treatments Exploring Investigating |
| Citations | 101 |
| Key findings | As of December 2020, 70 registered clinical trials investigate psychedelics for psychiatric disorders, with the majority studying MDMA and psilocybin for PTSD and major depressive disorder, and only 21 studies have published results. |
Abstract
Psychedelics are a hallucinogenic class of psychoactive drugs with the primary effect of activating non-ordinary states of consciousness. Due to the positive preliminary findings of these drugs in the treatment of psychiatric disorders, the number of registered clinical studies has risen significantly. In this paper, clinical studies registered on clinicaltrials.gov that evaluate the treatment of any psychiatric disorder with psychedelics (excluding ketamine) are summarized and analyzed. 70 registered studies were identified from a clinicaltrials.gov search on December 3, 2020. The majority of studies aim to investigate methylenedioxymethamphetamine (MDMA) (45.7%) and psilocybin (41.4%). Studies evaluating ayahuasca, lysergic acid diethylamide (LSD), ibogaine hydrochloride, salvia divinorum, 5-MeO-DMT and DMT fumarate were less common at 1.4%, 4.2%, 2.8%, 1.4%, 1.4% and 1.4% of total registered studies, respectively. Most of the studies on MDMA, psilocybin, ayahuasca and salvia divinorum investigated their therapeutic effect on post-traumatic stress disorder (PTSD) and major depressive disorder (MDD). LSD was investigated for MDD, anxiety, and severe somatic disorders and ibogaine hydrochloride was investigated for substance and alcohol use disorders. 5-MeO-DMT and DMT fumarate were both investigated for MDD. Only 21/70 registered studies had published results with the majority not yet completed. In view of the large number of ongoing studies investigating psychedelics, it is imperative that these studies are considered by researchers and stakeholders in deciding the most relevant research priorities for future proposed studies.