A pharmacologic comparison of 3,4-methylenedioxyamphetamine and LSD in the chronic spinal dog.
M Nozaki, D B Vaupel, W R Martin
European Journal of Pharmacology December 15, 1977 DOI: 10.1016/0014-2999(77)90228-x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experimental study Peer reviewed |
|---|---|
| Population | Dogs, including spinal dogs |
| Interventions | MDA LSD d-amphetamine cyproheptadine phenoxybenzamine chlorpromazine |
| Dose | MDA 2.0 and 2.2 mg/kg; LSD 10 microgram/kg; d-amphetamine 3.2 mg/kg |
| Topics | LSD |
| Key findings | MDA produced effects resembling both LSD and amphetamine in dogs: amphetamine-like pupil dilation, nictitating membrane retraction, stereotypy and darting eye movements, plus LSD-like flexor reflex facilitation, stepping, whining and eye tracking. Cyproheptadine antagonized LSD but not MDA, and cross tolerance to MDA after LSD tolerance was partial. MDA was one-tenth as potent as d-amphetamine in suppressing appetite. |
Abstract
MDA (2.0 and 2.2 mg/kg) was compared to LSD (10 microgram/kg) and d-amphetamine (3.2 mg/kg) in single dose, antagonism, cross tolerance and appetite suppression studies. In single doses MDA specifically resembled d-amphetamine by producing marked mydriasis, nictitating membrane retraction, stereotypy and darting eye movements and LSD by markedly facilitating the flex or reflex, producing continuous stepping, whining and eye tracking movements. LSD and MDA increased respiration, body temperature and the latency of the skin twitch reflex and produced behavioral arousal. Cyproheptadine antagonized the effects of LSD but was ineffective against MDA. Phenoxybenzamine antagonized the respiratory, pupillary and hyperthermic effects of MDA and the respiratory effect of LSD. Chlorpromazine antagonized many of the effects of LSD and MDA. Spinal dogs were made tolerant to the behavioral and physiologic effects of LSD. Cross tolerance developed to some but not all of the effects of MDA. In intact dogs MDA was 1/10 as potent as d-amphetamine in suppressing appetite. It is concluded that MDA has properties resembling both LSD and amphetamine.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 7
- Differences Between the Mechanism of Action of MDMA, MBDB, and the Classic Hallucinogens. Identification of a New Therapeutic Class: Entactogens Journal of Psychoactive Drugs October 1, 1986
- Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity Journal of Neuroscience August 1, 1988
- Stereochemical effects of 3,4-methylenedioxymethamphetamine (MDMA) and related amphetamine derivatives on inhibition of uptake of [3H]monoamines into synaptosomes from different regions of rat brain. Biochemical Pharmacology July 15, 1987
- The identification of LSD-like hallucinogens using the chronic spinal dog. Drug and Alcohol Dependence March 1, 1978
- Stimulus properties of 1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDA) analogs. Pharmacology, Biochemistry, and Behavior March 1988
and 2 more in the library