METABOLIC AND ENDOCRINE EFFECTS OF LYSERGIC ACID DIETHYLAMIDE (LSD-25) ON MALE RATS
A. S. Weltman, Arthur M. Sackler
Journal of Endocrinology 1966 DOI: 10.1677/joe.0.0340081 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experiment Peer reviewed |
|---|---|
| Population | Male Wistar rats |
| Intervention | Lysergic acid diethylamide (LSD-25) |
| Dose | 500 or 750 μg/kg |
| Duration | 2 weeks (eight injections on alternate days, last two on consecutive days) |
| Measures | Urinary 17-ketosteroid output, white blood cell counts, body weight, food and oxygen consumption |
| Topics | LSD |
| Key findings | The authors report that repeated LSD-25 injections in rats, depending on time and dosage, stimulated adrenal function, lowered metabolism, and inhibited thyroid and possibly gonadal function. They note similarities between LSD-25 intoxication and schizophrenia. |
Abstract
SUMMARY: Male Wistar rats were injected s.c. with 500 or 750 μg./kg. of lysergic acid diethylamide (LSD-25) on alternate days for 2 weeks and received a total of eight injections, the last two being on consecutive days. Before autopsy, urinary 17-ketosteroid output, white blood cell counts, body weight, food and oxygen consumption were studied. Depending on time and dosage, the various results indicate that LSD-25 stimulates adrenal function, lowers metabolism, and inhibits thyroid and possibly gonadal function. Similarities between the effects of LSD-25 intoxication and schizophrenia are noted.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 3
- LSD: Autoradiographic Study on the Placental Transfer and Tissue Distribution in Mice Science June 13, 1969
- Immunological Effects of Ayahuasca in Humans Journal of Psychoactive Drugs October 20, 2014
- Characterization of behavioral and endocrine effects of LSD on zebrafish. Behavioural Brain Research June 1, 2010