Association of serotonin transporter gene polymorphism and emotion regulation.
Hiroki Murakami, Masahiro Matsunaga, Hideki Ohira
Neuroreport March 1, 2009 DOI: 10.1097/wnr.0b013e328325a910 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Adults genotyped for the serotonin transporter gene polymorphism, classified as S homozygotes or SL individuals |
| Intervention | Metacognitive strategy of emotion regulation |
| Topics | Anxiety Serotonin |
| Keywords | Humans Analysis of variance Emotions Neuropsychological tests Heart rate Genotype Polymorphism, genetic Female Mind-body therapies Young adult |
| Key findings | S homozygotes showed more negative emotional states than SL individuals in both metacognition and control conditions. High-frequency heart rate variability increased in the metacognition condition only in S homozygotes, which the authors interpret as indicating that the metacognitive emotion-regulation strategy is more effective for increasing parasympathetic dominance in S homozygotes than in SL individuals. |
Abstract
Metacognitive strategies of emotion regulation such as an objective perspective of one's self are known as primary factors in mindfulness intervention. Earlier studies, however, suggest that the effect of mindfulness differs because of the individual variability. In this study, we investigated the influence of the serotonin transporter gene polymorphism during the application of a metacognitive strategy of emotion regulation. Short (S) homozygotes showed more negative emotional states than SL individuals in both metacognition and control conditions. The high frequency of heart rate variability, however, increased in the metacognition condition only in S homozygotes. This result indicated that the metacognitive strategy of emotion regulation is more effective for increasing parasympathetic dominance in S homozygotes than in SL individuals.
Comparable studies
Other experimental studies on serotonin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action Healthy human volunteers | 1998 | Experimental study | |
| Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin | 2000 | Experimental study | |
| Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity Rat brain | 1988 | Experimental study | |
| The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release. Human platelet plasma membrane vesicles and bovine adrenal chromaffin granule membrane... | 1992 | Laboratory study | |
| 5-HT2AReceptor-Mediated Regulation of Brain-Derived Neurotrophic Factor mRNA in the Hippocampus and the Neocortex Rat brain | 1997 | Experimental study |
Citations in the library
Cites 4
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- Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Journal of Consulting and Clinical Psychology 2000
- Metacognitive awareness and prevention of relapse in depression: Empirical evidence. Journal of Consulting and Clinical Psychology 2002