5-HT 1A polymorphism and self-transcendence in mood disorders.
Cristina Lorenzi, Alessandro Serretti, Laura Mandelli, Viviana Tubazio, Cristina Ploia, Enrico Smeraldi
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics August 5, 2005 DOI: 10.1002/ajmg.b.30111 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Genetic association study Peer reviewed |
|---|---|
| Sample size | 40 |
| Population | Remitted mood disorder patients |
| Measures | Temperament and Character Inventory (TCI) self-transcendence scale and its transpersonal identification and spiritual acceptance subscales |
| Topics | Serotonin |
| Key points | Patients with the 5-HT(1A)*C/C genotype had significantly lower total self-transcendence scores and lower transpersonal identification and spiritual acceptance subscale scores than other patients. The authors state these preliminary results support involvement of the serotonergic system in the self-transcendence character trait. |
Abstract
Recently, an association between serotonin 1A receptor binding potential and self-transcendence scores at the temperament and character inventory (TCI) has been reported. We tested involvement of 5-HT(1A) gene in this trait, in a sample of 40 remitted mood disorder patients. Subjects with the 5-HT(1A)*C/C genotype showed significantly lower scores at the total self-transcendence and at the sub-scales of transpersonal identification and spiritual acceptance. Our preliminary results further support the involvement of the serotoninergic pattern in the self-transcendence character trait.
Citations in the library
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- The Spiritual Brain: Selective Cortical Lesions Modulate Human Self-Transcendence Neuron February 1, 2010
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- Near-death and out-of-body experiences: A case for dialogue between scientist and theologian? Neurology and Religion 2019
- Serotonin 5-HT1A receptor binding and self-transcendence in healthy control subjects-a replication study using Bayesian hypothesis testing. PeerJ 2018
- Serotonin 5-HT 1A receptor binding and self-transcendence in healthy control subjects - a replication study using Bayesian hypothesis testing bioRxiv November 30, 2017
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