COMPARISON EFFECTIVENESS OF MBSR AND CBT ON INTERLEUKIN 6 AND OXIDATIVE STRESS IN HYPERTENSIVE PATIENTS
Behrooz Birashk, Farshad Sheybani, Banafsheh Gharraee, Mohammadreza Pirmoradi, Shokoufeh Hajsadeghi
International Journal of Life Science and Pharma Research July 4, 2018 DOI: 10.22376/ijpbs/lpr.2018.8.3.l39-45 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Sample size | 60 |
| Population | Patients with primary hypertension |
| Interventions | Mindfulness-based stress reduction (MBSR) Cognitive-behavioral therapy (CBT) |
| Measures | Prooxidant-antioxidant balance (PAB), ELISA (Biovendor kit) |
| Topics | Meditation |
| Citations | 2 |
| Key findings | MBSR significantly reduced oxidative stress, and both MBSR and CBT significantly reduced IL-6 levels in patients with primary hypertension; CBT did not significantly reduce oxidative stress. |
Abstract
Cardiovascular diseases are the leading cause of death in developing countries. Research has shown that the level of oxidative stress and interleukin 6 (IL-6) is higher in individuals with hypertension than individuals with normal blood pressure. Therefore, the aim of the present randomized clinical trial study was to compare the effectiveness of mindfulness-based stress reduction (MBSR) and cognitive-behavioral therapy (CBT) on oxidative stress and interleukin 6. Sixty patients with primary hypertension were divided into two intervention groups (MBSR and CBT) and one control group. Oxidative stress and IL-6 were measured by prooxidant-antioxidant balance (PAB) and ELISA method (Biovendor kit), respectively. Data analysis was carried out using ANOVA and MANCOVA in SPSS Ver.19. The results showed that MBSR significantly reduced oxidative stress. Also, MBSR and CBT significantly reduced IL-6 levels.
Comparable studies
Other randomized controlled trials on meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Alterations in Brain and Immune Function Produced by Mindfulness Meditation Healthy employees in a work environment | 2003 | Randomized controlled trial | n = 41 |
| Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients | 2000 | Randomized controlled trial | n = 145 |
| Open hearts build lives: Positive emotions, induced through loving-kindness meditation, build consequential personal resources. Working adults | 2008 | Randomized controlled trial | n = 139 |
| Short-term meditation training improves attention and self-regulation Undergraduate Chinese students | 2007 | Randomized controlled trial | n = 40 |
| Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Recovered recurrently depressed patients | 2004 | Randomized controlled trial | n = 73 |
Citations in the library
Cites 2
- Mindfulness‐Based Stress Reduction and Mindfulness‐Based Cognitive Therapy – a systematic review of randomized controlled trials Acta Psychiatrica Scandinavica April 28, 2011
- The Effect of Mindfulness-Based Therapy on Anxiety and Depression: A Meta-Analytic Review Journal of Consulting and Clinical Psychology April 1, 2010