Evaluating metabolites in patients with major depressive disorder who received mindfulness-based cognitive therapy and healthy controls using short echo MRSI at 7 Tesla.
Yan Li, Angela Jakary, Erin P Gillung, Stuart J. Eisendrath, Sarah J Nelson, Pratik Mukherjee, Tracy Luks
Magma June 2016 DOI: 10.1007/s10334-016-0526-7 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational case-control study with pre-post intervention component Peer reviewed |
|---|---|
| Sample size | 26 |
| Population | 16 unmedicated patients with major depressive disorder and 10 age- and gender-matched healthy controls |
| Intervention | Mindfulness-based cognitive therapy (MBCT) |
| Duration | 8-week course of MBCT |
| Topics | Depression Meditation |
| Keywords | 7 tesla |
| Key findings | Unmedicated patients with major depressive disorder differed from healthy controls in several brain metabolite ratios at 7 Tesla, including higher total choline-containing compounds/total creatine in the right caudate and lower N-acetyl aspartate/total creatine in the left anterior cingulate cortex. All patients' depression severity decreased after 8 weeks of mindfulness-based cognitive therapy, and improvement was associated with changes in N-acetyl aspartate/total creatine in the left anterior cingulate cortex. |
Abstract
Our aim was to evaluate differences in metabolite levels between unmedicated patients with major depressive disorder (MDD) and healthy controls, to assess changes in metabolites in patients after they completed an 8-week course of mindfulness-based cognitive therapy (MBCT), and to exam the correlation between metabolites and depression severity. Sixteen patients with MDD and ten age- and gender-matched healthy controls were studied using 3D short echo-time (20 ms) magnetic resonance spectroscopic imaging (MRSI) at 7 Tesla. Relative metabolite ratios were estimated in five regions of interest corresponding to insula, anterior cingulate cortex (ACC), caudate, putamen, and thalamus. In all cases, MBCT reduced severity of depression. The ratio of total choline-containing compounds/total creatine (tCr) in the right caudate was significantly increased compared to that in healthy controls, while ratios of N-acetyl aspartate (NAA)/tCr in the left ACC, myo-inositol/tCr in the right insula, and glutathione/tCr in the left putamen were significantly decreased. At baseline, the severity of depression was negatively correlated with my-inositol/tCr in the left insula and putamen. The improvement in depression severity was significantly associated with changes in NAA/tCr in the left ACC. This study has successfully evaluated regional differences in metabolites for patients with MDD who received MBCT treatment and in controls using 7 Tesla MRSI.
Comparable studies
Other non-randomized and open-label trials on depression, most cited first.
Citations in the library
Cited by 5
- Neural correlates of mindfulness meditation and hypnosis on magnetic resonance imaging: similarities and differences. A scoping review. Journal of neuroradiology = Journal de neuroradiologie March 1, 2024
- IMPLICAÇÕES NEUROLÓGICAS DA MEDITAÇÃO DO TIPO TERAPIA COGNITIVA BASEADA EM MINDFULNESS EM PACIENTES COM TRANSTORNO DE ANSIEDADE OU TRANSTORNO DEPRESSIVO: UMA REVISÃO INTEGRATIVA Arquivos de Ciências da Saúde da UNIPAR September 22, 2023
- Pallidum volume as a predictor for the effectiveness of mindfulness-based cognitive therapy and psycho-education in unmedicated patients with obsessive-compulsive disorder. Comprehensive Psychiatry May 1, 2024
- Evaluation of major depressive disorder using 7 Tesla phase sensitive neuroimaging before and after mindfulness-based cognitive therapy. Journal of Affective Disorders August 15, 2023
- Neural effects of mindfulness-based interventions on patients with major depressive disorder: A systematic review. Neuroscience & Biobehavioral Reviews May 2018
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