Neural effects of mindfulness-based interventions on patients with major depressive disorder: A systematic review.
Philippe Vignaud, Clément Donde, Thouraya Sadki, Emmanuel Poulet, Jérôme Brunelin
Neuroscience & Biobehavioral Reviews May 2018 DOI: 10.1016/j.neubiorev.2018.03.004 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review Peer reviewed |
|---|---|
| Population | Patients with major depressive disorder (MDD) |
| Intervention | Mindfulness-based interventions (MBIs) |
| Topics | Depression Meditation |
| Keywords | EEG Electroencephalography Neuroimaging |
| Key findings | The review reports that mindfulness-based interventions modulate activity in brain regions implicated in MDD, including the prefrontal cortex, basal ganglia, anterior and posterior cingulate cortices, and parietal cortex, which are involved in self-awareness, attention, and emotion regulation. Some findings were consistent with effects seen in healthy subjects and patients with other psychiatric disorders, especially enhanced frontal and subcortical activity related to improved somatosensory awareness. The authors conclude that further studies are needed to clarify the mechanisms of MBIs in MDD. |
Abstract
Growing evidence has suggested that mindfulness-based interventions (MBIs) could have beneficial effects on the acute phase of depression and on the prevention of depressive relapse or recurrence. Despite growing clinical interest, the effects of MBIs on brain functioning in patients with MDD remain unclear. The aim of this systematic review was to assess the changes in brain functioning associated with MBIs in patients with MDD. A systematic search was conducted, and of the 56 articles found, 8 were eligible. MBIs have modulatory effects on several brain regions implicated in the pathophysiology of MDD, such as the prefrontal cortex, the basal ganglia, the anterior and posterior cingulate cortices, and the parietal cortex. These regions have been implicated in self-awareness, attention and emotion regulation. Some of these findings were consistent with the effects of MBIs observed in healthy subjects and patients with other psychiatric disorders, especially enhanced activity in the frontal and subcortical regions related to the improved somatosensory awareness. Further studies are needed to elucidate the mechanisms of MBIs in MDD.
Comparable studies
Other systematic reviews and meta-analyses on depression, most cited first.
Citations in the library
Cited by 14
- Mindfulness-based interventions: an overall review British Medical Bulletin April 21, 2021
- A meta-analysis of the association between mindfulness and motivation Frontiers in Public Health August 8, 2023
- The effectiveness of mindfulness yoga on patients with major depressive disorder: a systematic review and meta-analysis of randomized controlled trials. BMC Complementary Medicine and Therapies September 8, 2023
- The dynamic framework of mind wandering revisited: How mindful meta-awareness affects mental states' constraints. Consciousness and Cognition October 1, 2021
- The meditative brain: State and trait changes in harmonic complexity for long-term mindfulness meditators bioRxiv (Cold Spring Harbor Laboratory) November 17, 2023
and 9 more in the library
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