Brief Mindfulness Intervention vs. Health Enhancement Program for Patients Undergoing Dialysis: A Randomized Controlled Trial
Marouane Nassim, Haley Park, Elena Dikaios, Angela Potes, Sasha Elbaz, Clare Mcveigh, Mark L. Lipman, Márta Novák, Emilie Trinh, Ahsan Alam, Rita S. Suri, Zoë Thomas, Susana Gabriela Torres-Platas, Akshya Vasudev, Neeti Sasi, Maryse Gautier, István Mucsi, Helen Rose Noble, Soham Rej
Healthcare June 1, 2021 DOI: 10.3390/healthcare9060659 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Sample size | 55 |
| Population | Patients receiving maintenance dialysis for end-stage kidney disease with symptoms of depression and/or anxiety |
| Intervention | Brief mindfulness intervention (BMI) |
| Duration | 8 weeks |
| Measures | Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7) |
| Topics | Meditation |
| Citations | 20 |
| Key findings | Both a brief mindfulness intervention and an active control (Health Enhancement Program) reduced depression symptoms in dialysis patients, with no difference between arms in secondary analyses. In participants with baseline PHQ-9 scores of 10 or higher, mindfulness produced greater improvement in depression scores, and mindfulness also appeared superior for anxiety symptoms in the primary analysis. The authors conclude both interventions may be helpful for depression, and mindfulness may be superior for anxiety. |
Abstract
Background: Between 20-50% of patients undergoing maintenance dialysis for end-stage kidney disease experience symptoms of depression and/or anxiety, associated with increased mortality, greater health care utilization, and decreased quality of life. It is unknown whether mindfulness-based interventions can improve depression and anxiety symptoms in patients receiving this treatment.
Methods: We conducted an 8-week multicenter randomized controlled trial comparing a brief mindfulness intervention (BMI) vs. an active control (Health Enhancement Program [HEP]) in 55 patients receiving dialysis with symptoms of depression and/or anxiety. The primary outcome was change in Patient Health Questionnaire-9 (PHQ-9) depression scores, with a primary analysis in participants with baseline PHQ-9 ≥ 10, and a secondary analysis including all participants. The secondary outcome was change in Generalized Anxiety Disorder-7 (GAD-7) anxiety scores with corresponding primary and secondary analyses.
Results: = 0.01). Secondary analyses revealed no differences between arms.
Conclusions: For patients undergoing dialysis, both BMI and HEP may be helpful interventions for depression symptoms, and BMI may be superior to HEP for anxiety symptoms. Mindfulness-based and other psychosocial interventions may be further evaluated in those undergoing dialysis as treatment options for symptoms of depression and anxiety.
Comparable studies
Other randomized controlled trials on meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Alterations in Brain and Immune Function Produced by Mindfulness Meditation Healthy employees in a work environment | 2003 | Randomized controlled trial | n = 41 |
| Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients | 2000 | Randomized controlled trial | n = 145 |
| Open hearts build lives: Positive emotions, induced through loving-kindness meditation, build consequential personal resources. Working adults | 2008 | Randomized controlled trial | n = 139 |
| Short-term meditation training improves attention and self-regulation Undergraduate Chinese students | 2007 | Randomized controlled trial | n = 40 |
| Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Recovered recurrently depressed patients | 2004 | Randomized controlled trial | n = 73 |
Citations in the library
Cited by 5
- Do Brief Mindfulness Interventions (BMI) and Health Enhancement Programs (HEP) Improve Sleep in Patients in Hemodialysis with Depression and Anxiety? Healthcare October 21, 2021
- Examining the acceptability and feasibility of the Compassionate Mindful Resilience (CMR) programme in adults living with chronic kidney disease: the COSMIC study findings. BMC nephrology January 31, 2024
- The Role of Mindfulness in Hemodialysis Patients: A Scoping Review Mindfulness September 9, 2026
- Long-term Effects of a Brief Mindfulness Intervention Versus a Health Enhancement Program for Treating Depression and Anxiety in Patients Undergoing Hemodialysis: A Randomized Controlled Trial. Can J Kidney Health Dis March 4, 2022
- Effects of mindfulness meditation on trait mindfulness, perceived stress, emotion regulation, and quality of life in hemodialysis patients: A randomized controlled trial International Journal of Nursing Science March 1, 2022
Cites 10
- Mindfulness-based cognitive therapy for depression August 21, 2006
- Efficacy of Mindfulness-based Stress Reduction in Hemodialysis Patients with Anxiety and Depression: a randomized, double-blind, parallel-group trial Electronic Physician January 22, 2020
- Face-to-Face and Internet-Based Mindfulness-Based Cognitive Therapy Compared With Treatment as Usual in Reducing Psychological Distress in Patients With Cancer: A Multicenter Randomized Controlled Trial. Journal of Clinical Oncology June 28, 2018
- Effectiveness of group cognitive behavioral therapy with mindfulness in end-stage renal disease hemodialysis patients. Kidney research and clinical practice March 2018
- The acceptability and potential benefits of mindfulness-based interventions in improving psychological well-being for adults with advanced cancer: A systematic review. Complementary Therapies in Clinical Practice February 2018
and 5 more in the library