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Evaluation of mindfulness based stress reduction in symptomatic knee or hip osteoarthritis patients: a pilot randomized controlled trial.

Clémentine Marais, Yujie Song, Rosanna Ferreira, Safa Aounti, Claire Duflos, Grégory Baptista, Yves-Marie Pers

BMC rheumatology May 30, 2022 DOI: 10.1186/s41927-022-00277-9 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Randomized, physician-blind clinical trial (pilot) Pilot study Peer reviewed
Sample size 40
Population Adults with symptomatic knee or hip osteoarthritis
Intervention Mindfulness-based stress reduction (MBSR)
Duration 8-week intervention; follow-up at 3 and 6 months
Measures WOMAC pain score, pain VAS, WOMAC scores, SF-36, HAD scores
Topics Meditation
Keywords Hip osteoarthritis Knee osteoarthritis Pain Randomized clinical trial
Registration NCT03644615
Key findings MBSR produced no benefit on WOMAC pain or function at 3 or 6 months compared with usual care, and other secondary outcomes showed a similar pattern. A delayed reduction in pain VAS favored MBSR at 6 months (-29.6 vs -9.3 points). The authors describe these results as contrasting and call for larger studies to confirm them.

Abstract

To evaluate the efficacy for symptomatic knee and hip osteoarthritis (OA) patients of a mindfulness-based stress reduction (MBSR) program versus usual care. Randomized, physician-blind, clinical trial in a monocentric prospective pilot study. Adult participants with symptomatic knee or hip OA were randomized into either intervention or control groups. The intervention group completed the MBSR program for a two-and-a-half-hour weekly session for 8 weeks. Usual care management was similar in both groups. All patients were evaluated at baseline, 3 months and 6 months. The primary objective was to evaluate the change in WOMAC pain score between baseline and 3 months in the MBSR group compared to usual care group. Secondary objectives were to evaluate changes in pain VAS, WOMAC scores, quality of life (SF-36), HAD scores between baseline and 3/6 months. Forty patients were enrolled in the study. No differences in the WOMAC pain score between the two groups were observed in the different time points. A similar pattern was found for the other assessment outcomes. However, a significant pain VAS reduction in favor of the MBSR group between baseline and 6 months (- 29.6 ± 26.6 vs - 9.3 ± 27.3; p = 0.03) has been reached. Our pilot RCT found contrasting results with no benefit on WOMAC pain and function and a delayed but long-term efficacy in pain VAS following a MBSR program in symptomatic knee or hip OA patients. Future studies with larger sample size are mandatory to confirm these preliminary results. Trial registration The study was registered in ClinicalTrials.gov (NCT03644615, 23/08/2018).

Comparable studies

Other randomized controlled trials on meditation, most cited first.

Study Year Design Participants
Alterations in Brain and Immune Function Produced by Mindfulness Meditation Healthy employees in a work environment 2003 Randomized controlled trial n = 41
Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients 2000 Randomized controlled trial n = 145
Open hearts build lives: Positive emotions, induced through loving-kindness meditation, build consequential personal resources. Working adults 2008 Randomized controlled trial n = 139
Short-term meditation training improves attention and self-regulation Undergraduate Chinese students 2007 Randomized controlled trial n = 40
Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Recovered recurrently depressed patients 2004 Randomized controlled trial n = 73

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