Systematic Review and Meta-analysis: Mindfulness-Based Interventions for Rheumatoid Arthritis.
Dana D. DiRenzo, Monica Crespo-Bosque, Neda F Gould, Patrick H. Finan, Julie Nanavati, Clifton O. Bingham
Current rheumatology reports October 18, 2018 DOI: 10.1007/s11926-018-0787-4 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review Randomized Peer reviewed |
|---|---|
| Sample size | 399 |
| Population | Patients with rheumatoid arthritis |
| Intervention | Mindfulness-based interventions |
| Measures | DAS28-CRP, Visual Analog Scale (VAS) |
| Topics | Meditation |
| Keywords | Humans Arthritis, rheumatoid Stress Rheumatoid arthritis Systematic review Mindfulness-based interventions |
| Key findings | Across five randomized trials and one post-hoc analysis (399 participants), meta-analyses found no statistically significant effects of mindfulness-based interventions on DAS28-CRP disease activity or pain VAS, though individual studies reported some improvements. All four studies assessing psychological outcomes reported improvements in depressive symptoms, psychological distress, and self-efficacy. The authors suggest MBIs may be a useful strategy for psychological distress in RA, while noting the evidence base is small. |
Abstract
Purpose of review: To determine the efficacy of mindfulness-based interventions (MBIs) on clinical and patient-reported outcomes in rheumatoid arthritis (RA). Recent findings: We identified randomized clinical trials from inception through April 2018 from MEDLINE, PsycINFO, EMBASE, CINAHL, Web of Science, the Cochrane Library, and hand searches. After screening 338 references, we included five trials with one post-hoc analysis that evaluated MBIs and collectively included 399 participants. Outcome instruments were heterogeneous across studies. Three studies evaluated RA clinical outcomes by a rheumatologist; one study found improvements in disease activity. A limited meta-analysis found no statistically significant difference in the levels of DAS28-CRP in the two studies that evaluated this metric (- 0.44 (- 0.99, 0.12); I2 0%). Four studies evaluated heterogeneous psychological outcomes, and all found improvements including depressive symptoms, psychological distress, and self-efficacy. A meta-analysis of pain Visual Analog Scale (VAS) levels post intervention from three included studies was not significantly different between MBI participants and control group (- 0.58 (- 1.26, 0.10); I2 0%) although other studies not included in meta-analysis found improvement. There are few trials evaluating the effect of MBIs on outcomes in patients with RA. Preliminary findings suggest that MBIs may be a useful strategy to improve psychological distress in those with RA.
Comparable studies
Other systematic reviews and meta-analyses on meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Meditation Programs for Psychological Stress and Well-being Diverse adult clinical populations | 2014 | Meta-analysis | n = 3,515 |
| Mindfulness-Based Stress Reduction for Stress Management in Healthy People: A Review and Meta-Analysis Healthy subjects | 2009 | Systematic review and meta-analysis | |
| The psychological effects of meditation: A meta-analysis. Nonclinical groups of adult meditators | 2012 | Meta-analysis | n = 163 |
| Efficacy of Mindfulness-Based Cognitive Therapy in Prevention of Depressive Relapse Adults with recurrent depression in full or partial remission | 2016 | Meta-analysis of individual patient data from randomized controlled trials | n = 1,258 |
| Mindfulness‐Based Stress Reduction and Mindfulness‐Based Cognitive Therapy – a systematic review of randomized controlled trials | 2011 | Systematic review |
Citations in the library
Cited by 7
- From Self-Esteem to Selflessness: An Evidence (Gap) Map of Self-Related Processes as Mechanisms of Mindfulness-Based Interventions Frontiers in Psychology November 22, 2021
- Feasibility and acceptability of using a meditation app in adults with rheumatic disease. Explore November 9, 2021
- MITIG.RA: study protocol of a tailored psychological intervention for managing fatigue in rheumatoid arthritis randomized controlled trial. Trials October 6, 2023
- Modified-Mindfulness-Based Stress Reduction as a Treatment for Cognitive Recovery in Patients with Minor Stroke: a Randomized Controlled Pilot Study. medRxiv November 11, 2024
- Person-Centered Mindfulness: A Culturally and Spiritually Sensitive Approach to Clinical Practice. Journal of Religion and Health June 2023
and 2 more in the library
Cites 11
- The benefits of being present: Mindfulness and its role in psychological well-being. Journal of Personality and Social Psychology 2003
- Meditation Programs for Psychological Stress and Well-being JAMA Internal Medicine January 6, 2014
- Mindfulness-Based Stress Reduction as a Stress Management Intervention for Healthy Individuals Journal of Evidence-Based Complementary & Alternative Medicine July 22, 2014
- Effect of Mindfulness‐Based stress reduction in rheumatoid arthritis patients Arthritis Care & Research September 28, 2007
- Mindfulness-Based Interventions for Anxiety and Depression Psychiatric Clinics of North America September 18, 2017
and 6 more in the library