Altered dynamic effective connectivity of the default mode network in type 2 diabetes
Kun Xu, Jun Wang, Guangyao Liu, Jiahao Yan, Miao Chang, Linzhen Jiang, Jing Zhang
Frontiers in Neurology January 15, 2024 DOI: 10.3389/fneur.2023.1324988 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational case-control study Peer reviewed |
|---|---|
| Sample size | 76 |
| Population | 36 patients with Type 2 diabetes mellitus and 40 healthy controls |
| Measures | MoCA, HbA1c |
| Topics | Default mode network |
| Key findings | Dynamic effective connectivity within the default mode network was decreased in Type 2 diabetes patients only in state 1, with causal information flow mainly affecting regions tied to food craving and metabolic regulation. Patients spent longer in a low-activity state and transitioned between states less often, and these changes correlated negatively with MoCA scores and positively with HbA1c. |
Abstract
IntroductionAltered functional connectivity of resting-state functional magnetic resonance imaging (rs-fMRI) within default mode network (DMN) regions has been verified to be closely associated with cognitive decline in patients with Type 2 diabetes mellitus (T2DM), but most studies neglected the fluctuations of brain activities—the dynamic effective connectivity (DEC) within DMN of T2DM is still unknown.MethodsFor the current investigation, 40 healthy controls (HC) and 36 T2DM patients have been recruited as participants. To examine the variation of DEC between T2DM and HC, we utilized the methodologies of independent components analysis (ICA) and multivariate granger causality analysis (mGCA).ResultsWe found altered DEC within DMN only show decrease in state 1. In addition, the causal information flow of diabetic patients major affected areas which are closely associated with food craving and metabolic regulation, and T2DM patients stayed longer in low activity level and exhibited decreased transition rate between states. Moreover, these changes related negatively with the MoCA scores and positively with HbA1C level.ConclusionOur study may offer a fresh perspective on brain dynamic activities to understand the mechanisms underlying T2DM-related cognitive deficits.
Comparable studies
Other observational and cohort studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| A default mode of brain function Normal adult human brain | 2001 | Observational study | |
| Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network Healthy subjects | 2008 | Observational cohort | |
| Meditation experience is associated with increased cortical thickness Participants with extensive Insight meditation experience and matched controls | 2005 | Observational cohort | n = 20 |
| Meditation experience is associated with differences in default mode network activity and connectivity Experienced meditators and matched meditation-naive controls | 2011 | Observational cohort | |
| The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis Healthy subjects | 2008 | Observational study |