Potentiation of DOM-induced stimulus control by fluoxetine and citalopram: role of pharmacokinetics.
Justin R Eckler, Mireille M Doat, R A Rabin, Jerrold C Winter
Life Sciences August 2, 2002 DOI: 10.1016/s0024-3205(02)01861-1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal behavioral pharmacology study (drug discrimination) Peer reviewed |
|---|---|
| Population | Rats trained to discriminate DOM from saline |
| Interventions | DOM Citalopram Fluoxetine |
| Dose | DOM 0.6 mg/kg; citalopram 1.0 mg/kg |
| Key points | Citalopram (1.0 mg/kg) shifted the DOM dose-response relationship to the left in rats discriminating DOM, indicating potentiation of DOM's discriminative stimulus effects. This occurred without significant partial substitution by citalopram, and brain-level data showed fluoxetine but not citalopram increased DOM levels, leading the authors to conclude the effect is not mediated by additivity or pharmacokinetic mechanisms. |
Abstract
The present investigation examined the interaction between 2,5-dimethoxy-4-methylamphetamine [DOM] and the selective serotonin reuptake inhibitor [SSRI] citalopram in rats trained with DOM [0.6 mg/kg; 75 min pretreatment time] as a discriminative stimulus. Pretreatment with citalopram at a dose of 1.0 mg/kg shifted the DOM dose response relationship to the left. Unlike previously tested SSRI's, the enhancement of DOM-induced stimulus control occurred in the absence of significant partial substitution by citalopram. DOM brain levels were measured using a GC-MS method both in the presence and absence of citalopram and fluoxetine in order to evaluate the pharmacokinetic contribution to the observed behavioral effect. The data indicated that fluoxetine but not citalopram significantly increased DOM brain levels. It is concluded that the effects of DOM as a discriminative stimulus are potentiated by the acute administration of citalopram and this effect is not mediated by additivity or pharmacokinetic mechanisms.
Citations in the library
Cited by 4
- Serotonergic/glutamatergic interactions: potentiation of phencyclidine-induced stimulus control by citalopram. Pharmacology, Biochemistry, and Behavior July 2005
- A 5-HT(2C) receptor-mediated interaction between 2,5-dimethoxy-4-methylamphetamine and citalopram in the rat. Pharmacology, Biochemistry, and Behavior September 2004
- Nefazodone in the rat: mimicry and antagonism of [-]-DOM-induced stimulus control. Pharmacology, Biochemistry, and Behavior May 2003
- The effects of acute and subchronic treatment with fluoxetine and citalopram on stimulus control by DOM. Pharmacology, Biochemistry, and Behavior December 2002
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