Interactions between serotonergic agonists and antagonists in rats trained with LSD as a discriminative stimulus.
Pharmacology, Biochemistry, and Behavior July 1988 DOI: 10.1016/0091-3057(88)90074-3 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal drug discrimination study Peer reviewed |
|---|---|
| Population | Rats trained to discriminate 0.1 mg LSD from saline |
| Interventions | LSD 5-methoxy-dimethyltryptamine (MDMT) 2 5-dimethoxy-4-methyl-amphetamine (DOM) 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) m-trifluoromethylphenyl-piperazine (TFMPP) 5-methoxy-3-(1 3 6-tetrahydro-4-pyridinyl)-1H-indole (RU-24969) pizotyline pirenperone |
| Dose | 0.1 mg LSD |
| Topics | LSD Serotonin |
| Key points | DOM fully substituted for the LSD cue, and pizotyline and pirenperone blocked both DOM and LSD, whereas MDMT, 8-OH-DPAT, TFMPP, and RU-24969 substituted only partially and were variably affected by the antagonists. Unexpectedly, pizotyline and pirenperone potentiated the stimulus or disruptive effects of certain doses of 8-OH-DPAT and TFMPP, which the authors suggest indicates more complex drug interactions than previously assumed. |
Abstract
Drugs purported to have selective affinities for 5-HT1A, 5-HT1B, and 5-HT2 receptors were tested in rats trained with 0.1 mg LSD versus saline. Included were 5-methoxy-dimethyltryptamine (MDMT), 2,5-dimethoxy-4-methyl-amphetamine (DOM), 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), m-trifluoromethylphenyl-piperazine (TFMPP), and 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (RU-24969). Tests were then repeated in the presence of either pizotyline or pirenperone. DOM substituted for LSD and both were blocked by pizotyline and pirenperone. MDMT, 8-OH-DPAT, TFMPP, and RU-24969 substituted less completely and were variably affected by the antagonists. An unexpected result was potentiation of the stimulus or disruptive effects of certain doses of 8-OH-DPAT and TFMPP by pizotyline and pirenperone. The present findings suggest more complex interactions between these drugs than has previously been assumed.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
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Cites 8
- Role of serotonin in the discriminative stimulus properties of mescaline Pharmacology, Biochemistry, and Behavior May 1, 1975
- Mescaline and lysergic acid diethylamide (LSD) as discriminative stimuli Psychopharmacology 1971
- Comparative discriminative stimulus effects of 5-methoxy-N,N-dimethyltryptamine and LSD. Life Sciences June 14, 1982
- Behavioral effects of 5-methoxy-N,N-dimethyltryptamine and dose-dependent antagonism by BC-105. Psychopharmacology 1983
- Mechanistic studies on DOM as a discriminative stimulus. Pharmacology, Biochemistry, and Behavior December 1985
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