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Mechanistic studies on DOM as a discriminative stimulus.

Richard A Glennon, A E Hauck

Pharmacology, Biochemistry, and Behavior December 1985 DOI: 10.1016/0091-3057(85)90096-6 (opens in new tab)

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Characteristics Animal behavioral pharmacology experiment (drug discrimination study) Peer reviewed
Sample size 10
Population Rats
Interventions Racemic DOM lisuride 8-OH DPAT LY-53 857 ritanserin CP-52 215 THT
Dose DOM 1.0 mg/kg, IP
Key findings Lisuride generalized to the DOM stimulus while 8-OH DPAT did not, and the 5-HT2-affinity compounds LY-53,857, ritanserin, CP-52,215, and THT each attenuated the DOM stimulus. The authors argue these results support the hypothesis that DOM produces its stimulus effects via a 5-HT2-related mechanism.

Abstract

Ten rats were trained to discriminate racemic DOM (1.0 mg/kg, IP) from saline using a standard two-lever operant procedure. Once responding was stable, these animals were administered doses of lisuride and the purported 5-HT1 agonist 8-OH DPAT in tests of stimulus generalization. DOM-stimulus generalization occurred with lisuride, but not with 8-OH DPAT. These animals were also administered doses of LY-53,857, ritanserin, CP-52,215, and THT in tests of stimulus antagonism. Each of these agents possesses a significant affinity for 5-HT2 binding sites, and each effectively attenuated the DOM-stimulus. These results, coupled with our earlier findings, support the hypothesis that DOM may be producing its stimulus effects via a 5-HT2-related mechanism.

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