A review of recent studies of the biosynthesis and excretion of hallucinogens formed by methylation of neurotransmitters or related substances.
H Rosengarten, A J Friedhoff
Schizophrenia Bulletin 1976 DOI: 10.1093/schbul/2.1.90 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Serotonin |
| Keywords | Humans Norepinephrine Dopamine Tryptamines N,N-Dimethyltryptamine Ethylamines Dimethoxyphenylethylamine Carbolines Bufotenin Folic acid Alcohol oxidoreductases Methyltransferases S-adenosylmethionine Hallucinogens Schizophrenia Methylation |
| Key findings | The review surveys evidence that hallucinogens such as DMT, bufotenin, and DMPEA can be formed by methylation of neurotransmitters and excreted in humans, but the authors argue that a causal role for these compounds in schizophrenia or other psychiatric disorders is not established and requires further study. |
Abstract
Helen Rosengarten, M.D., Arnold J. Friedhoff, M.D.; A Review of Recent Studies of the Biosynthesis and Excretion of Hallucinogens Formed by Methylation of Neuro
Comparable studies
Other narrative reviews on serotonin, most cited first.
Citations in the library
Cited by 8
- N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function Frontiers in Neuroscience August 6, 2018
- Serotonin, But Not N -Methyltryptamines, Activates the Serotonin 2A Receptor Via a β-Arrestin2/Src/Akt Signaling Complex In Vivo Journal of Neuroscience October 6, 2010
- Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT Psychopharmacology January 22, 2022
- The evolution of N, N-Dimethyltryptamine: from metabolic pathways to brain connectivity. Psychopharmacology April 11, 2025
- Cerebral and peripheral demethylation of psychotomimetics measured by expired 14CO2. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1989
and 3 more in the library
Cites 3
- Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds Science August 4, 1961
- Untoward Reactions to Lysergic Acid Diethylamide (LSD) Resulting in Hospitalization New England Journal of Medicine December 2, 1965
- Behavioral effects of 5-methoxy-N:N-dimethyltryptamine, other tryptamines, and LSD American Journal of Physiology-Legacy Content July 1, 1962