Cerebral and peripheral demethylation of psychotomimetics measured by expired 14CO2.
Thornton W. Sargent, U Braun, Gisela Braun, N Kusubov, K S Bristol
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1989 DOI: 10.1016/0883-2897(89)90219-5 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Citations | 2 |
| Key findings | 5-Methoxy-N,N-dimethyltryptamine was not demethylated, and 2,4,5-trimethoxyphenalkylamines were demethylated less in the brain than peripherally, particularly at the p-methoxy position. |
Abstract
Demethylation of psychotomimetic compounds was measured by labeling each methyl and methoxy substitutent separately with 14C and injecting it into rats, intravenously and intracerebrally. Expired [14C]CO2 was measured continuously and the resultant multi-exponential curves yielded rates and integral demethylation. 5-Methoxy-N,N-dimethyltryptamine was not demethylated, eliminating one proposed metabolic pathway. 2,4,5-Trimethoxyphenalkylamines were demethylated less in the brain than peripherally, markedly so at the p-methoxy position, suggesting a possible biochemical site for endogenous induction of psychosis.