Title: DMT, Salvinorin A, and Stress Regulation: An Exploratory Neuropharmacological Research Proposal
Peter McGrath
Zenodo (CERN European Organization for Nuclear Research) October 21, 2026 preprint DOI: 10.5281/zenodo.23540286 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper |
|---|---|
| Topics | DMT Salvia divinorum |
| Key points | Proposes a neuropharmacological research framework comparing the serotonergic mechanisms of N,N-DMT with the kappa-opioid receptor activity of salvinorin A in relation to emotional arousal, dissociation, stress physiology, and memory processing, while also considering possible links between physical exercise, environmental exposures, and stress regulation. The proposal reports no original human-subject experiments, clinical interventions, or treatment outcomes, and does not propose either substance as an established treatment for PTSD. |
Abstract
Title: DMT, Salvinorin A, and Stress Regulation: An Exploratory Neuropharmacological Research Proposal Creator: Peter McGrath Affiliation: Appalachian State University Resource type: Publication — Working Paper Description: This independent undergraduate research proposal examines differences between the serotonergic mechanisms of N,N-DMT and the kappa-opioid receptor activity of salvinorin A, with particular attention to emotional arousal, dissociation, stress physiology, and memory processing. The proposal also considers the potential relationships between ordinary physical exercise, environmental exposures, and stress regulation. It is a theoretical research framework supported by existing scientific literature. No original human-subject experiments, clinical interventions, or treatment outcomes are reported. Neither substance is proposed as an established treatment for PTSD.
Comparable studies
Other theoretical and historical papers on salvia divinorum, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Total synthesis of the hallucinogenic neoclerodane diterpenoid salvinorin A. | 2008 | Theoretical or philosophical paper | |
| The claustrum's proposed role in consciousness is supported by the effect and target localization of Salvia divinorum. | 2014 | Theoretical or philosophical paper | |
| Total Synthesis of (-)-Salvinorin A. | 2016 | Theoretical or philosophical paper | |
| Salvia Divinorum: entrSalvia divinorum: Entre la prohibición y la construcción de su conocimientoe a proibição e a construção do seu saber | 2022 | Theoretical or philosophical paper | |
| Salvia divinorum induces body awareness changes comparable to metamorphic symptoms in the Alice in Wonderland syndrome | 2019 | Theoretical or philosophical paper |