Total synthesis of the hallucinogenic neoclerodane diterpenoid salvinorin A.
Masato Nozawa, Yuhki Suka, Takashi Hoshi, Toshio Suzuki, Hisahiro Hagiwara
Organic Letters April 3, 2008 DOI: 10.1021/ol800101v (opens in new tab) via PubMed
Summary
AI-generated from the abstractA potent hallucinogen, Salvinorin A, recognized for its unique effects on the brain, has been successfully created in the lab. Scientists achieved its total synthesis in 20 precise steps, starting from a foundational chemical compound. This significant accomplishment offers a controlled method to produce this intricate molecule, enabling deeper understanding and diverse applications.
Study at a glance
| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | Salvia divinorum |
| Keywords | Chemical synthesis Hallucinogens Neuroscience |
| Citations | 63 |
| Key finding | Describes a 20-step total synthesis of salvinorin A from an enantiomerically pure hydroxy-Wieland-Miescher ketone. |
Abstract
Total synthesis of salvinorin A (1), a neoclerodane diterpenoid having the most potent hallucinogenic activity and a selective kappa-opioid agonist, was completed in 20 steps starting from enantiomerically pure hydroxy-Wieland-Miescher ketone 5.