Phospholipase C mediates (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-, but not lysergic acid diethylamide (LSD)-elicited head bobs in rabbit medial prefrontal cortex.
Brain Res November 1, 2012 DOI: 10.1016/j.brainres.2012.10.057 (opens in new tab) via PubMed Central
Summary
AI-generated from the abstractIn the rabbit medial prefrontal cortex, the head-bob behavior elicited by the psychedelic compound DOI is mediated by phospholipase C, whereas the head-bob behavior elicited by LSD is not. This finding indicates that different signaling pathways underlie the behavioral effects of these two psychedelic drugs.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rabbit medial prefrontal cortex |
| Interventions | DOI LSD |
| Key finding | Phospholipase C mediates DOI-elicited head bobs but not LSD-elicited head bobs in rabbit medial prefrontal cortex. |
Abstract
Phospholipase C mediates (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-, but not lysergic acid diethylamide (LSD)-elicited head bobs in rabbit medial prefrontal cortex.