Phospholipase C mediates (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-, but not lysergic acid diethylamide (LSD)-elicited head bobs in rabbit medial prefrontal cortex.

Brain Res November 1, 2012 DOI: 10.1016/j.brainres.2012.10.057 (opens in new tab)

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Characteristics	Experimental study Peer reviewed
Population	Rabbit medial prefrontal cortex
Interventions	DOI LSD
Topics	LSD
Key findings	Phospholipase C mediates DOI-elicited head bobs but not LSD-elicited head bobs in rabbit medial prefrontal cortex.

Abstract

Phospholipase C mediates (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-, but not lysergic acid diethylamide (LSD)-elicited head bobs in rabbit medial prefrontal cortex.

Serotonergic and dopaminergic distinctions in the behavioral pharmacology of (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) Pharmacology Biochemistry and Behavior December 15, 2011 18 citations
5-HT2A receptor-stimulated phosphoinositide hydrolysis in the stimulus effects of hallucinogens. Pharmacology, biochemistry, and behavior May 2002
Intrahippocampal LSD accelerates learning and desensitizes the 5-HT(2A) receptor in the rabbit, Romano et al. Psychopharmacology October 1, 2010 42 citations
Imaging Brain Phospholipase A2 Activation in Awake Rats in Response to the 5-HT2A/2C Agonist (±)2,5-Dimethoxy-4-Iodophenyl-2-Aminopropane (DOI) Neuropsychopharmacology February 1, 2003
Antagonism of 5-hydroxytryptamine2 receptor-mediated phosphatidylinositol turnover by d-lysergic acid diethylamide. Journal of Pharmacology and Experimental Therapeutics December 1, 1988

Study at a glance

Abstract

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