Correlation of performance test scores with “tissue concentration” of lysergic acid diethylamide in human subiects
John G. Wagner, George K. Aghajanian, O. Bing
Clinical Pharmacology & Therapeutics September 1, 1968 DOI: 10.1002/cpt196895635 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Pharmacokinetic modeling study Peer reviewed |
|---|---|
| Dose | 2 mcg per kilogram |
| Topics | LSD |
| Keywords | Compartment ship Body weight Extracellular fluid Plasma concentration Animal science Biochemistry |
| Citations | 61 |
| Key points | The two-compartment open model explains LSD-25 plasma concentrations, and arithmetic test performance correlates linearly with tissue compartment concentration. |
Abstract
Previously published plasma concentrations of LSD‐25, observed following intravenous iniection of 2 mcg. per kilogram of LSD‐25, have been found to be explained by the two‐compartment open model. Performance scores on arithmetic tests were shown to be highly linearly correlated with the concentration in the “tissue” (outer) compartment. The estimated volume of the plasma (inner) compartment was 16.3 per cent of body weight, which is approximately the value reported for extracellular water; the estimated volume of the tissue compartment was 11.5 per cent of body weight. The estimated half‐life for loss of LSD‐25 from the plasma compartment, based on the model, was 103 minutes compared with a half‐life of 180 minutes calculated directly from plasma concentrations.