Mindfulness-based Cognitive Therapy for Psychological Distress, Fear of Cancer Recurrence, Fatigue, Spiritual Wellbeing and Quality of Life in Patients with Breast Cancer - a Randomized Control Trial.
Sunre Park, Yasuko Sato, Yuka Takita, Noriko Tamura, Akira Ninomiya, Teppei Kosugi, Mitsuhiro Sado, Atsuo Nakagawa, Maiko Takahashi, T. Hayashida, Daisuke Fujisawa
Journal of Pain and Symptom Management February 24, 2020 DOI: 10.1016/j.jpainsymman.2020.02.017 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Sample size | 74 |
| Population | Japanese ambulatory patients with stage I to III breast cancer |
| Intervention | Mindfulness-based cognitive therapy |
| Duration | 8-week intervention, 4-week follow-up |
| Topics | Meditation |
| Key findings | MBCT significantly improved psychological distress, fear of cancer recurrence, fatigue, spiritual wellbeing, and quality of life compared with a wait-list control, with effects maintained at four-week follow-up. |
Abstract
CONTEXT Mindfulness-based interventions have been receiving growing attention in cancer care.
Objectives: The purpose of this randomized controlled trial is to examine the effectiveness of mindfulness-based cognitive therapy (MBCT) for psychological distress (anxiety and depression), fear of cancer recurrence (FCR), fatigue, spiritual wellbeing and quality of life (QOL) in Japanese ambulatory patients with stage I to III breast cancer.
Methods: A total of 74 patients were randomly assigned to either an eight-week MBCT intervention group (n = 38) or a wait-list control group (n = 36). The primary outcome was psychological distress, measured on Hospital Anxiety and Depression Scale. The secondary outcomes were FCR (Concerns About Recurrence Scale - overall anxiety subscale), fatigue (Brief Fatigue Inventory), spiritual well-being (Functional Assessment of Chronic Illness Therapy-Spiritual), QOL (Functional Assessment of Cancer Therapy-General) and mindfulness skills (Five Facet Mindfulness Questionnaire). The participants were assessed at baseline (T0), week8 (T1), and week12 (T2). The results were analyzed using a linear mixed model, intention-to-treat.
Results: The participants in the MBCT group experienced significantly better outcomes in their psychological distress (Cohen's d=1.17, p<0.001), FCR (d=0.43 p<0.05), fatigue (d=0.66, p<0.01), spiritual wellbeing (d=0.98, p<0.001) and QOL (d=0.79, p<0.001) compared with the control group. The difference remained significant at T2 (four weeks after completion of the intervention).
Conclusions: MBCT was demonstrated to improve wellbeing that encompasses psychological, physical and spiritual domains in Japanese patients with nonmetastatic breast cancer. The favorable effect was maintained up to four weeks after the completion of the intervention.
Comparable studies
Other randomized controlled trials on meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Alterations in Brain and Immune Function Produced by Mindfulness Meditation Healthy employees in a work environment | 2003 | Randomized controlled trial | n = 41 |
| Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients | 2000 | Randomized controlled trial | n = 145 |
| Open hearts build lives: Positive emotions, induced through loving-kindness meditation, build consequential personal resources. Working adults | 2008 | Randomized controlled trial | n = 139 |
| Short-term meditation training improves attention and self-regulation Undergraduate Chinese students | 2007 | Randomized controlled trial | n = 40 |
| Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Recovered recurrently depressed patients | 2004 | Randomized controlled trial | n = 73 |
Citations in the library
Cited by 41
- Psychosocial-spiritual well-being is related to resilience and mindfulness in patients with severe and/or life-limiting medical illness BMC Palliative Care September 11, 2023
- Effectiveness of a Mindfulness Meditation App Based on an Electroencephalography-Based Brain-Computer Interface in Radiofrequency Catheter Ablation for Patients With Atrial Fibrillation: Pilot Randomized Controlled Trial. JMIR mHealth and uHealth May 3, 2023
- Effects of Mindfulness-Based Interventions on Depression in Patients With Breast Cancer: A Systematic Review and Meta-Analysis. Integrative Cancer Therapies 2023
- Combined Mindfulness-Based Stress Reduction and Exercise Intervention for Improving Psychological Well-Being in Patients With Non-Small Cell Lung Cancer. Clinical Psychology & Psychotherapy 2024
- Effectiveness of Web-Based Mindfulness-Based Interventions for Patients With Cancer: Systematic Review and Meta-Analyses. Journal of Medical Internet Research June 25, 2024
and 36 more in the library
Cites 11
- Mindfulness‐based interventions for psychological and physical health outcomes in cancer patients and survivors: A systematic review and meta‐analysis of randomized controlled trials Psycho-Oncology September 11, 2019
- Mindfulness training and systemic low-grade inflammation in stressed community adults: Evidence from two randomized controlled trials PLoS One July 11, 2019
- Mindfulness-based cognitive therapy for Japanese breast cancer patients-a feasibility study. Japanese journal of clinical oncology January 1, 2018
- Mindfulness-based interventions for women with breast cancer: an updated systematic review and meta-analysis. Acta oncologica December 2017
- Does mindfulness meditation improve chronic pain? A systematic review Current Opinion in Obstetrics & Gynecology December 1, 2017
and 6 more in the library