Free Your Mind and Mental Health and Wellbeing Will Follow: Evidence from Across-Day Within-Person Mediation in an Eight-Week Mindfulness RCT
Paul Verhaeghen, Shelley N. Aikman, Nilam Ram
Mindfulness March 26, 2026 DOI: 10.1007/s12671-026-02820-y (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Preregistered Peer reviewed |
|---|---|
| Sample size | 264 |
| Population | College students |
| Intervention | Mindfulness intervention |
| Duration | Eight-week intervention, daily measures |
| Topics | Meditation |
| Keywords | Mental health Rumination Moderation Moderated mediation Cognition Clinical psychology Randomized controlled trial Psychotherapist Intervention counseling Cognitive reappraisal Mindfulness meditation |
| Key findings | Mindfulness improves mental health and wellbeing by reducing rumination and cognitive interference and increasing self-compassion and self-transcendent emotions. |
Abstract
Abstract Objectives The study aimed to identify the within-person mediating mechanisms linking state mindfulness to mental health, wellbeing, and compassion.
Method: Participants (133 college students going through an eight-week mindfulness intervention, and 131 waitlist controls) provided daily measures of predictors (facets of mindfulness), mediators (rumination, cognitive interference, self-compassion, and self-transcendent emotions), and outcomes (mental health, wellbeing, and compassion). One-day lagged within-person mediation models were applied to test for mediation effects.
Results: We obtained complete or partial mediation for all outcome variables except compassion; cognitive interference was the strongest mediator. Effects of the acceptance facet of mindfulness were mediated through rumination, cognitive interference, and self-compassion; the effects of the monitoring aspect through self-compassion and self-transcendent emotions. Moderation analyses showed that the mindfulness intervention did not modify the strength of existing causal pathways. We also obtained positive correlations between meditation and mindfulness practice and state mindfulness.
Conclusions: The findings strongly suggest a causal flow of influence, where mindfulness (as enhanced through meditation and informal practices) boosts mental health and wellbeing by reducing rumination and cognitive interference and increasing self-compassion and self-transcendence. Mindfulness thus can free the mind from excessive self-preoccupation, thereby improving mental health and wellbeing. Preregistration : This study is not preregistered.
Comparable studies
Other randomized controlled trials on meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Alterations in Brain and Immune Function Produced by Mindfulness Meditation Healthy employees in a work environment | 2003 | Randomized controlled trial | n = 41 |
| Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients | 2000 | Randomized controlled trial | n = 145 |
| Open hearts build lives: Positive emotions, induced through loving-kindness meditation, build consequential personal resources. Working adults | 2008 | Randomized controlled trial | n = 139 |
| Short-term meditation training improves attention and self-regulation Undergraduate Chinese students | 2007 | Randomized controlled trial | n = 40 |
| Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Recovered recurrently depressed patients | 2004 | Randomized controlled trial | n = 73 |
Citations in the library
Cites 21
- The benefits of being present: Mindfulness and its role in psychological well-being. Journal of Personality and Social Psychology 2003
- Using Self-Report Assessment Methods to Explore Facets of Mindfulness Assessment January 27, 2006
- Mindfulness: A proposed operational definition. Clinical Psychology Science and Practice 2004
- Mindfulness training as a clinical intervention: A conceptual and empirical review. Clinical Psychology Science and Practice 2003
- Mechanisms of mindfulness Journal of Clinical Psychology December 29, 2005
and 16 more in the library