A rapid narrative review of the clinical evolution of psychedelic treatment in clinical trials.
Ronit Kishon, Nadav Liam Modlin, Yael M. Cycowicz, Hania Mourtada, Tayler Wilson, Victoria Williamson, Anthony J. Cleare, James Rucker
npj Mental Health Research July 2, 2024 DOI: 10.1038/s44184-024-00068-9 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Randomized Peer reviewed |
|---|---|
| Topics | Psychedelic-assisted therapy |
| Keywords | Mental health treatment Clinical research Alternative medicine Therapeutic breakthroughs |
| Citations | 22 |
| Key findings | Pre-prohibition psychedelic research provides valuable clinical insights into treatment methodologies and the role of non-pharmacological factors, which can inform modern research and clinician training. |
Abstract
Pre-prohibition psychedelic research with complex psychiatric patients generated a wealth of treatment methodologies and practices, providing invaluable clinical insights pertaining to the medical administration of psychedelics in various mental health diagnoses. Building upon these early studies, which lack the rigor and research tools available today, contemporary psychedelic research has focused on investigating the safety and efficacy of psychedelics in randomized controlled trials via psychometric measures and symptom assessments. Both then and now, the treatment context and the role of clinicians in psychedelic treatment has been recognized as an essential feature for positive patient outcomes. To broaden the knowledge base of modern psychedelic research and support the training of clinicians conducting medically supervised psychedelic research studies, this paper provides a review of pre-prohibition clinical research narratives pertaining to the phenomenology of psychedelic treatment and the role of the non-pharmacological treatment factors in the patient experience. Lastly, this paper explores a range of clinician perspectives and psychological interventions employed in pre-prohibition psychedelic research to inform future research directions and best practice guidelines.
Comparable studies
Other narrative reviews on psychedelic-assisted therapy, most cited first.
Citations in the library
Cited by 17
- Uncovering Psychedelics: From Neural Circuits to Therapeutic Applications Pharmaceuticals January 19, 2025
- Psychedelic iatrogenic structural dissociation: an exploratory hypothesis on dissociative risks in psychedelic use. Frontiers in Psychology March 4, 2025
- Historians on Drugs: Toward an Empirical Historiography of Global Psychedelic Cultures South Atlantic Quarterly April 1, 2025
- Clinical and preclinical evidence of psilocybin as antidepressant. A narrative review Progress in Neuro-Psychopharmacology and Biological Psychiatry 2025
- Regulatory Challenges of Integrating Psychedelics into Mental Health Sector Psychoactives April 22, 2025
and 12 more in the library
Cites 61
- Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial Journal of Psychopharmacology November 30, 2016
- Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study. The Lancet Psychiatry May 17, 2016
- Human hallucinogen research: guidelines for safety. Journal of Psychopharmacology July 1, 2008
- Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study Journal of Psychopharmacology January 13, 2015
- Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression. New England Journal of Medicine November 3, 2022
and 56 more in the library