Ethical and Practical Considerations for the Use of Psychedelics in Psychiatry
Gregory S. Barber, Charles C. Dike
Psychiatric Services March 29, 2023 DOI: 10.1176/appi.ps.20220525 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Citations | 63 |
| Key findings | Psychedelic-assisted psychotherapies remain investigational, and ethical considerations—including informed consent, patient vulnerability, and equity—are critical before they can be approved for general clinical use. |
Abstract
In recent years, psychedelic-assisted psychotherapies have reentered the realm of rigorous scientific inquiry, garnering much attention from both the psychiatric community and the broader public. Headlines on major media platforms frequently tout the psychedelic future of psychiatry, and patients increasingly ask about the prospect of using psychedelics during their sessions. Despite this enthusiasm, psychedelics remain in an investigational stage, and more research and regulatory work are required before psychedelics can be deemed appropriate for general clinical use. In this climate, psychiatrists are increasingly curious about the prospects of psychedelic treatments. This review's goal was to help psychiatrists better understand the complexities of the burgeoning field of psychedelic-assisted psychotherapy. The discussion encompasses issues surrounding psychedelics in their current investigational stage and issues for psychiatrists to consider should psychedelics become available for broad clinical use. This review discusses research equipoise in the context of the current enthusiasm for psychedelics, informed consent, patient vulnerability, equity and access, differences between clinical and nonclinical psychedelic uses, and psychedelic self-enhancement. As psychedelics move closer toward regulatory approval beyond research settings, it is vital that these promising treatments be used ethically. The unique features of psychedelic therapies, including the altered states of consciousness they produce and the vulnerability that such states entail for patients, require careful consideration to minimize potential ethical pitfalls. This review seeks to ensure that psychiatrists are equipped to use psychedelic psychotherapy both ethically and effectively.
Citations in the library
Cited by 45
- Psychedelic-assisted psychotherapy: where is the psychotherapy research? Psychopharmacology August 1, 2024
- Distinctive But Not Exceptional: The Risks of Psychedelic Ethical Exceptionalism. The American Journal of Bioethics 2025
- Spiritual health practitioners’ contributions to psychedelic assisted therapy: A qualitative analysis PLoS One January 2, 2024
- Practical considerations in the establishment of psychedelic research programs. Psychopharmacology 2025
- Emerging Medications for Treatment-Resistant Depression: A Review with Perspective on Mechanisms and Challenges Brain Sciences February 6, 2025
and 40 more in the library
Cites 41
- Trial of Psilocybin versus Escitalopram for Depression New England Journal of Medicine April 14, 2021
- Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder JAMA Psychiatry November 4, 2020
- Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study Journal of Psychopharmacology January 13, 2015
- MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study. Nature Medicine June 1, 2021
- Mystical experiences occasioned by the hallucinogen psilocybin lead to increases in the personality domain of openness Journal of Psychopharmacology September 28, 2011
and 36 more in the library