Hyperlocomotion Test for Assessing Behavioral Disorders.

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AI-extracted from the abstract

Characteristics	Protocol Peer reviewed
Population	Rats
Keywords	Behavioral deficits Hyperlocomotion test Nutritional programming Pcp Psychosis
Key points	The hyperlocomotion test can assess behavioral symptoms such as psychosis or mania in rats using an acute PCP-injection model.

Abstract

Under- or overfeeding during pregnancy can lead to behavioral deficits in the offspring in later life. Here, we present a protocol for setting up and carrying out the hyperlocomotion test for assessing behavioral symptoms such as psychosis or mania. As an example, we use the acute rat phencyclidine-injection model which exhibits hyperlocomotion and stereotypic behaviors, resembling the positive symptoms of schizophrenia.

Reassessment of amphetamine- and phencyclidine-induced locomotor hyperactivity as a model of psychosis-like behavior in rats. Journal of Integrative Neuroscience January 28, 2022
A PSYCHO-PHARMACOLOGICAL ANALYSIS OF BEHAVIOUR IN RATS The Japanese Journal of Pharmacology 1971 78 citations
Temporal dissociation of phencyclidine: Induced locomotor and social alterations in rats using an automated homecage monitoring system - implications for the 3Rs and preclinical drug discovery. Journal of psychopharmacology (Oxford, England) July 1, 2020
Hyperresponsiveness to phencyclidine in animals lesioned in the amygdala on day 7 of life. Implications for an animal model of schizophrenia. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology August 1, 2003
Effects of continuous D-amphetamine and phencyclidine administration on social behaviour, stereotyped behaviour, and locomotor activity in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology July 1, 1998

Study at a glance

Abstract

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