Phencyclidine-induced psychosis.
R M Allen, S J Young
American Journal of Psychiatry September 1978 DOI: 10.1176/ajp.135.9.1081 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case series Case report Peer reviewed |
|---|---|
| Sample size | 9 |
| Population | Patients with phencyclidine-induced psychosis admitted to Darnall Army Hospital |
| Intervention | Antipsychotic medication |
| Duration | 13-month period |
| Key findings | Phencyclidine-induced psychosis often persisted beyond 30 days despite antipsychotic treatment, with symptoms resembling schizophrenia, leading the authors to propose PCP as a drug model for schizophrenia. |
Abstract
During a 13-month period, 9 patients with phencyclidine-induced psychosis were admitted to Darnall Army Hospital. They exhibited hostility agitation, and tangentiality and had delusions of influence and religious grandiosity. Six subjects reported auditory hallucinations, and 4 were disoriented in at least 1 sphere. Despite treatment with antipsychotic medication, the psychotic episodes often persisted for more than 30 days. Our clinical finding of prolonged psychotic reactions, together with previous reports of the effects of phencyclidine, suggests that phenycyclidine provides an intriguing drug model for schizophrenia.
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