Transient hypolocomotion in rats repeatedly exposed to phencyclidine: an appraisal of motor function and motivation.
Marie-Claude Audet, Sonia Goulet, François Y Doré
Progress in neuro-psychopharmacology & biological psychiatry January 30, 2007 DOI: 10.1016/j.pnpbp.2006.08.006 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | Phencyclidine (PCP) periodic auditory stimulation |
| Dose | 10 mg/kg |
| Duration | Injection period with a 7-day washout |
| Key findings | Repeated 10 mg/kg PCP injections reduced spontaneous locomotion in rats during the injection period, but the effect did not persist after a 7-day washout. Motor coordination and motivation were unaffected. The authors propose the hypolocomotion reflects an inability to self-generate behaviors in contexts where response production is not clearly specified or supported, regardless of reward contingency. |
Abstract
Spontaneous locomotion in rats is reduced about 20 h following phencyclidine (PCP) exposure. Our primary purpose was to test if locomotor irregularities would outlast drug withdrawal and be modulated by a periodic auditory stimulation during or after repeated injections. To circumscribe plausible interpretations, motor coordination and motivation were assessed as well. 10 mg/kg of PCP decreased spontaneous locomotion during the injection period whether or not a sound was presented. Those effects did not persist after a 7-day washout. Motor coordination and motivation to perform a variety of goal-driven conducts in the presence or absence of reinforcement were all unaffected by PCP treatment. The generalized hypolocomotor effects induced by PCP likely resulted from an inability to self-generate behaviors. These deficiencies were apparent in contexts where response production was not clearly specified nor supported, regardless of reward contingency.
Citations in the library
Cited by 2
- Delayed alternation performance following subchronic phencyclidine administration in rats depends on task parameters. Progress in Neuro-Psychopharmacology and Biological Psychiatry June 30, 2007
- Enhanced anxiety follows withdrawal from subchronic exposure to phencyclidine in rats. Behavioural Brain Research January 25, 2007