Two cases of "cannabis acute psychosis" following the administration of oral cannabis
Bernard Favrat, Annick Ménétrey, Marc Augsburger, Laura E. Rothuizen, Monique Appenzeller, Thierry Buclin, Marie A. Pin, Patrice Mangin, Christian Giroud
BMC Psychiatry December 1, 2005 DOI: 10.1186/1471-244x-5-17 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case report Peer reviewed |
|---|---|
| Sample size | 2 |
| Population | Healthy occasional but regular cannabis users with no psychiatric history |
| Intervention | Oral cannabis |
| Topics | Cannabis |
| Key findings | Oral cannabis can induce transient psychotic symptoms in occasional users even with limited blood concentrations. |
Abstract
Abstract Background Cannabis is the most commonly used illegal drug and its therapeutic aspects have a growing interest. Short-term psychotic reactions have been described but not clearly with synthetic oral THC, especially in occasional users. Case presentations We report two cases of healthy subjects who were occasional but regular cannabis users without psychiatric history who developed transient psychotic symptoms (depersonalization, paranoid feelings and derealisation) following oral administration of cannabis. In contrast to most other case reports where circumstances and blood concentrations are unknown, the two cases reported here happened under experimental conditions with all subjects negative for cannabis, opiates, amphetamines, cocaine, benzodiazepines and alcohol, and therefore the ingested dose, the time-events of effects on behavior and performance as well as the cannabinoid blood levels were documented. Conclusion While the oral route of administration achieves only limited blood concentrations, significant psychotic reactions may occur.
Comparable studies
Other case reports and case series on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psychotic Reactions Following Cannabis Use in East Indians Patients at an Indian drug addiction clinic who developed acute cannabis-related psychosis | 1974 | Descriptive report (case series of clinical observations) | n = 200 |
| Psychiatric effects of cannabis use Swedish cases of cannabis psychosis | 1985 | Case series | n = 70 |
| Forty-Six Cases of Psychosis in Cannabis Abusers Gunila Bernhardson Habitual cannabis users treated for psychosis at Swedish psychiatric clinics and mental... | 1972 | Case series (retrospective survey of psychiatric records) | n = 46 |
| Hallucinogen persisting perception disorder after psilocybin consumption: a case study 18-year-old man with HPPD after mixed psilocybin and cannabis intoxication | 2005 | Case study | n = 1 |
| Cannabis‐induced Koro in Americans American men aged 22-26 with years of cannabis experience who reported negative... | 2001 | Case series | n = 3 |
Citations in the library
Cited by 20
- Acute Effects of a Single, Oral dose of d9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) Administration in Healthy Volunteers Current Pharmaceutical Design September 12, 2012
- The thalamus in psychosis spectrum disorder. Frontiers in Neuroscience 2023
- Assessing rates and predictors of cannabis-associated psychotic symptoms across observational, experimental and medical research Nature Mental Health June 3, 2024
- Aversiveness and Meaningfulness of Uncomfortable Experiences with Edible Cannabis Journal of Psychoactive Drugs July 29, 2019
- Revisión sobre el consumo de cannabis como factor de riesgo de la esquizofrenia Adicciones June 1, 2007
and 15 more in the library
Cites 14
- Causal association between cannabis and psychosis: examination of the evidence The British Journal of Psychiatry January 30, 2004
- Psychiatric effects of cannabis The British Journal of Psychiatry February 1, 2001
- Psychotic Reactions Following Cannabis Use in East Indians Archives of General Psychiatry 1974
- A Clinical and Metabolic Study of Acute Intoxication with Cannabis Sativa and its Role in the Model Psychoses Journal of Mental Science October 1, 1958
- Marihuanann Psychosis JAMA October 13, 1969
and 9 more in the library