Synthesis, absolute configuration and in vitro cytotoxicity of deschloroketamine enantiomers: rediscovered and abused dissociative anaesthetic
Bronislav Jurásek, František Králík, Silvie Rimpelová, Jan Čejka, Vladimı́r Setnička, Tomáš Ruml, Martin Kuchař, Michal Kohout
New Journal of Chemistry 2018 DOI: 10.1039/c8nj03107j (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | In vitro study Peer reviewed |
|---|---|
| Population | Nine different cell lines |
| Keywords | Dissociative Enantiomer Absolute configuration Cytotoxicity In vitro Stereochemistry Pharmacology Biochemistry |
| Citations | 15 |
| Key points | The absolute configuration of deschloroketamine enantiomers was elucidated, and their in vitro cytotoxicity was determined across nine cell lines. |
Abstract
Deschloroketamine has been synthesized, the absolute configuration of enantiomers elucidated and the in vitro cytotoxicity of the enantiomers determined using nine different cell lines.
Citations in the library
Cited by 4
- Pharmacokinetic, pharmacodynamic, and behavioural studies of deschloroketamine in Wistar rats. British Journal of Pharmacology 2022
- Structure identification and analysis of the suspected chemical precursor of 2-fluorodeschloroketamine and its decomposition products. Drug Testing and Analysis June 1, 2022
- Rewarding and reinforcing effects of two dissociative-based new psychoactive substances, deschloroketamine and diphenidine, in mice. Pharmacology, Biochemistry, and Behavior February 1, 2022
- The crystal structures of methoxmetamine hydrochloride and methoxetamine hydrochloride determined from laboratory X-ray powder diffraction data contained in the Powder Diffraction File ™ Powder Diffraction December 1, 2025
Cites 12
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- A REVIEW OF KETAMINE ABUSE AND DIVERSION Depression and Anxiety August 1, 2016
- Ketamine treatment for depression: opportunities for clinical innovation and ethical foresight. The Lancet Psychiatry April 5, 2017
and 7 more in the library