Comparison of the action of lysergic acid diethylamide and apomorphine on the copulatory response in the female rat
Mona Eliasson, Bengt J. Meyerson
Psychopharmacology 1976 DOI: 10.1007/bf00426833 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Ovariectomized estrogen + progesterone-treated rats |
| Interventions | LSD apomorphine pimozide chlorpromazine |
| Dose | 0.10 mg/kg (LSD), 0.2 mg/kg (apomorphine), 0.1 and 0.5 mg/kg (pimozide), 0.5 mg/kg (chlorpromazine) |
| Topics | LSD Serotonin |
| Keywords | Copulatory behavior Apomorphine Pimozide Dopamine antagonism Chlorpromazine |
| Citations | 34 |
| Key findings | LSD's inhibition of lordosis is not primarily due to increased dopamine receptor activity but may involve decreased dopaminergic activity. |
Abstract
The effects of lysergic acid diethylamide (LSD) and apomorphine were compared using female copulatory behavior (lordosis response), in ovariectomized estrogen + progesterone-treated rats. Both serotonin and dopamine are implicated in the inhibition of this behavior. Each compound inhibited lordosis behavior dose dependently and with a similar time-course. Pimozide (0.1; 0.5 mg/kg) blocked the apomorphine (0.2 mg/kg)-induced decrease of lordosis response, while only a certain abbreviation of the LSD (0.10 mg/kg) inhibition was achieved by pimozide (0.5 mg/kg). Chlorpromazine (0.5 mg/kg) in a dose without effects on lordosis of its own had an action similar to pimozide on the LSD effect. It is concluded that the predominant action of LSD on the female coupulatory response is not mediated by increased dopamine receptor activity but that the LSD effect might be modulated by decreased dopaminergic activity.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cites 4
- Evidence for a central 5‐hydroxytryptamine receptor stimulation by lysergic acid diethylamide British Journal of Pharmacology September 1, 1968
- Lysergic acid diethylamide: evidence for stimulation of cerebral dopamine receptors Brain Research August 1, 1975
- Studies on the Diethylamide of Lysergic Acid (LSD-25) A M A Archives of Neurology & Psychiatry April 1, 1957
- Psychopharmacological Studies of Lysergic Acid Diethylamide (LSD-25) Intoxication A M A Archives of Neurology & Psychiatry December 1, 1957