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Microdosing of LSD does not show efficacy in adults with ADHD

The Brown University Psychopharmacology Update July 1, 2025 DOI: 10.1002/pu.31324 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Phase 2A trial Peer reviewed
Population Adults with attention-deficit hyperactivity disorder (ADHD)
Intervention LSD
Duration 6-week intervention
Topics LSD Microdosing
Key findings Microdosing LSD over six weeks showed no significant benefits over placebo in reducing ADHD symptoms in adults.

Abstract

Microdosing of lysergic acid diethylamide (LSD) over a 6‐week period showed no significant benefits over placebo in reducing symptoms of attention‐deficit hyperactivity disorder (ADHD) in adults, a Phase 2A trial has found. Both the LSD and placebo groups experienced marked improvement, the investigators reported.

Comparable studies

Other non-randomized and open-label trials on LSD and microdosing, most cited first.

Study Year Design Participants
An open-label pilot trial assessing tolerability and feasibility of LSD microdosing in patients with major depressive disorder (LSDDEP1). Patients with major depressive disorder meeting DSM-5 criteria 2023 Open-label pilot trial n = 20
LSD microdosing in major depressive disorder: results from an open-label trial Participants with major depressive disorder, most taking antidepressant medication 2025 Open-label phase 2A trial n = 19
Evaluating the Potential of Microdosing 1cp-LSD for the Treatment of Canine Anxiety: A One-Month Case Study. A 13-year-old female dog with severe separation anxiety 2025 Pilot study, single-case study n = 1
LSD microdosing for major depressive disorder: Mood and pharmacokinetic outcomes from a Phase 2a trial People with depression 2026 Clinical trial
What is it like to microdose LSD for depression? a thematic analysis of participant interviews from an open-label trial. Adults with major depressive disorder 2025 Open-label pilot trial (phase IIa) with post-intervention qualitative interviews n = 17

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