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What is it like to microdose LSD for depression? a thematic analysis of participant interviews from an open-label trial.

Carina Joy Donegan, Dimitri Daldegan-Bueno, Rachael Sumner, Anna Forsyth, Will Evans, Nicholas Hoeh, Frederick Sundram, David B Menkes, Suresh Muthukumaraswamy, Lisa Reynolds

Ther Adv Psychopharmacol December 4, 2025 DOI: 10.1177/20451253251396253 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Thematic analysis of interviews from an open-label trial Peer reviewed
Population People with depression who microdosed LSD in an open-label trial
Topics Depression LSD
Key findings Participants reported improved mood, increased energy, and greater emotional openness, alongside some negative experiences like anxiety.

Abstract

What is it like to microdose LSD for depression? a thematic analysis of participant interviews from an open-label trial.