LSD degrades hippocampal spatial representations and suppresses hippocampal-visual cortical interactions
Carli Domenico, Daniel Haggerty, Xiang Mou, Daoyun Ji
Cell Reports September 17, 2021 DOI: 10.1016/j.celrep.2021.109714 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | Lysergic acid diethylamide (LSD) |
| Topics | LSD |
| Keywords | Place cells Lysergic acid deithylamide Visual cortex Hippocampus Spatial navigation Hallucination |
| Citations | 16 |
| Key findings | LSD suppresses hippocampal-cortical interactions during active behavior and immobility, leading to degraded and isolated internal hippocampal representations that may contribute to abnormal perceptions. |
Abstract
Summary: Lysergic acid diethylamide (LSD) produces hallucinations, which are perceptions uncoupled from the external environment. How LSD alters neuronal activities in vivo that underlie abnormal perceptions is unknown. Here, we show that when rats run along a familiar track, hippocampal place cells under LSD reduce their firing rates, their directionality, and their interaction with visual cortical neurons. However, both hippocampal and visual cortical neurons temporarily increase firing rates during head-twitching, a behavioral signature of a hallucination-like state in rodents. When rats are immobile on the track, LSD enhances cortical firing synchrony in a state similar to the wakefulness-to-sleep transition, during which the hippocampal-cortical interaction remains dampened while hippocampal awake reactivation is maintained. Our results suggest that LSD suppresses hippocampal-cortical interactions during active behavior and during immobility, leading to internal hippocampal representations that are degraded and isolated from external sensory input. These effects may contribute to LSD-produced abnormal perceptions.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 10
- The neural basis of psychedelic action. Nature Neuroscience October 24, 2022
- Ventral hippocampal parvalbumin interneurons gate the acute anxiolytic action of the serotonergic psychedelic DOI. Neuron November 20, 2024
- Bedside to bench: the outlook for psychedelic research Frontiers in Pharmacology October 2, 2023
- Cellular rules underlying psychedelic control of prefrontal pyramidal neurons bioRxiv (Cold Spring Harbor Laboratory) October 23, 2023
- How Psychedelics Modulate Multiple Memory Mechanisms in Posttraumatic Stress Disorder. Drugs November 1, 2024
and 5 more in the library
Cites 21
- Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin Proceedings of the National Academy of Sciences January 23, 2012
- Neural correlates of the LSD experience revealed by multimodal neuroimaging. Proceedings of the National Academy of Sciences April 11, 2016
- Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution. Current Biology April 13, 2016
- The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network PLoS One February 18, 2015
- Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects Biological Psychiatry November 29, 2014
and 16 more in the library