LSD degrades hippocampal spatial representations and suppresses hippocampal-visual cortical interactions
Cell Reports September 17, 2021 Carli Domenico, Daniel Haggerty, Xiang Mou et al. 16 citations
Summary: Lysergic acid diethylamide (LSD) produces hallucinations, which are perceptions uncoupled from the external environment. How LSD alters neuronal activities in vivo that underlie abnormal perceptions is unknown. Here, we show that when rats run along a familiar track, hippocampal place cells under LSD reduce their firing rates, their directionality, and their interaction with visual...