Chromosomal Damage in Human Leukocytes Induced by Lysergic Acid Diethylamide
Maimon M. Cohen, Michelle J. Marinello, Nathan Back
Science March 17, 1967 DOI: 10.1126/science.155.3768.1417 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Cultured human leukocytes and one human patient |
| Intervention | Lysergic acid diethylamide |
| Duration | 4-year period for the patient |
| Topics | LSD |
| Citations | 199 |
| Key findings | LSD exposure in cultured human leukocytes and in one patient led to a marked increase in chromosomal abnormalities, with breaks accumulating in chromosome 1. |
Abstract
Addition of lysergic acid diethylamide to cultured human leukocytes resulted in a marked increase of chromosomal abnormalities. The distribution of chromosome breaks deviated significantly from random, with an accumulation of aberrations in chromosome No. 1. Cytogenetic investigation of a patient extensively treated with this drug over a 4-year period for paranoid schizophrenia showed a similar increase in chromosomal damage.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 39
- Human hallucinogen research: guidelines for safety. Journal of Psychopharmacology July 1, 2008
- The Pharmacology of Lysergic Acid Diethylamide: A Review CNS Neuroscience & Therapeutics November 11, 2008
- Adverse effects of psychedelics: From anecdotes and misinformation to systematic science. Journal of Psychopharmacology February 2, 2022
- Clinical applications of hallucinogens: A review. Experimental and Clinical Psychopharmacology August 1, 2016
- In Vivo and in Vitro Chromosomal Damage Induced by LSD-25 New England Journal of Medicine November 16, 1967
and 34 more in the library