Pharmacokinetic parameters of mescaline in rabbits
C. Van Peteghem, A. Heyndrickx, W. Van Zele
European Journal of Drug Metabolism and Pharmacokinetics 1982 DOI: 10.1007/bf03189535 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Pharmacokinetic study Peer reviewed |
|---|---|
| Sample size | 4 |
| Population | Rabbits |
| Intervention | Mescaline |
| Topics | Mescaline |
| Keywords | Pharmacokinetics Steady state chemistry Distribution mathematics Human physiology Clinical chemistry Pharmacology Chromatography Mathematical analysis Biochemistry Organic chemistry |
| Citations | 3 |
| Key points | Mescaline pharmacokinetics in rabbits conforms to a two-compartment open model. |
Abstract
By means of a highly specific and sensitive mass fragmentographic method mescaline was measured in rabbit plasma samples, taken at various points after an i.v. injection. The pharmacokinetic behaviour conformed to the two-compartment open model. Half-life times of alpha and beta phases, velocity constants and steady-state distribution volumes of four subjects are reported.
Comparable studies
Other experimental studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds Rabbit lung | 1961 | Experimental study | |
| PSYCHOTOMIMETICS, CLINICAL AND THEORETICAL CONSIDERATIONS: HARMINE, WIN-2299 AND NALLINE Schizophrenic patients | 1957 | Experimental study | |
| Phencyclidine, Lysergic Acid Diethylamide, and Mescaline: Cerebral Artery Spasms and Hallucinogenic Activity Isolated basilar and middle cerebral arteries | 1981 | Experimental study | |
| Acquired and Crossed Tolerance to Mescaline, LSD-25, and BOL-148 | 1959 | Experimental study | |
| Effects of Hallucinogenic and Tranquilizing Drugs on Serotonin Evoked Uterine Contractions. Uterus of spayed rat | 1956 | Experimental study |