Disposition of 14C-mescaline by rabbit lung.
Robert A. Roth, Jan Roth, C. N. Gillis
Journal of Pharmacology and Experimental Therapeutics February 1, 1977 DOI: 10.1016/s0022-3565(25)30783-4 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | In vitro and ex vivo experimental study Peer reviewed |
|---|---|
| Population | Rabbit tissues (lung, liver, kidney, brain, plasma) and isolated rabbit lungs |
| Interventions | mescaline semicarbazide pargyline |
| Duration | 15 minutes (for in vitro activity measurement) |
| Topics | Mescaline |
| Keywords | Pargyline Semicarbazide Metabolite Monoamine oxidase In vivo Lung Pharmacology Metabolism In vitro Kidney Endocrinology Biochemistry |
| Citations | 17 |
| Key findings | Rabbit lung tissue metabolizes mescaline four times more actively than liver or kidney, and the intact lung removes perfused mescaline, suggesting a role in clearing circulating mescaline in vivo. |
Abstract
Metabolism of mescaline by several rabbit tissues was examined in vitro. Mescaline-oxidizing activity (micromoles per milligram of protein/15 min) of lung homogenates was 4 times greater than that of either liver or kidney. Brain and plasma each had comparatively little capacity to metabolize mescaline. Mescaline metabolism in vitro was sensitive to inhibition by semicarbazide. Removal of mescaline from the medium perfusing the isolated rabbit lung was explained by intrapulmonary metabolism. Semicarbazide (10(-3) M pargyline. Semicarbazide-treated lungs accumulated more mescaline than did untreated lungs. Mescaline efflux from lung was slower than that of its metabolite. These results indicate that the intact lung removes perfused mescaline and may be important in the disposition of circulating mescaline in vivo.