paraChlorophenylalanine potentiates facilitatory effects of mescaline on shuttlebox escape/avoidance in rats
David M. Stoff, Richard Jed Wyatt, J. Christian Gillin
Psychopharmacology 1976 DOI: 10.1007/bf00427615 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Hooded rats |
| Interventions | parachlorophenylalanine (pCPA) mescaline |
| Dose | 150 mg/kg pCPA, 39.6 mg/kg mescaline |
| Duration | 24 hours pretreatment with pCPA before mescaline; testing during acquisition and in stable pretrained poor avoiders |
| Topics | Mescaline Serotonin |
| Keywords | Avoidance response Dopamine Avoidance learning Norepinephrine |
| Citations | 6 |
| Key findings | pCPA pretreatment potentiated mescaline's facilitatory effects on avoidance behavior, but the combination led to long-term poor avoidance performance. |
Abstract
Acute parachlorophenylalanine (pCPA) pretreatment (150 mg/kg, i.p., 24 h beforehand) potentiated facilitatory effects of mescaline (39.6 mg/kg i.p.) on shuttlebox escape/avoidance in hooded rats, tested in two different situations: 1. during aquisition of avoidance behavior (Experiment 1); and 2. in stable pretrained poor avoiders (Experiment 2). pCPA alone did not influence avoidance behavior in either situation. Mescaline, with pCPA pretreatment, may be associated with long-term behavioral effects; all rats treated with this combination were later found to be poor avoiders, unable to achieve a stable baseline of good avoidance. pCPA significantly depleted brain norepinephrine and dopamine, as well as serotonin, measured after testing in the second situation.
Comparable studies
Other preclinical and animal studies on mescaline, most cited first.
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| Brain mechanisms of hallucinogens and entactogens Humans and rats | 2001 | Review | |
| Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Zebrafish (Danio rerio) | 2012 | Experimental study | |
| Lysergic Acid Diethylamide- and Mescaline-Induced Attenuation of the Effect of Punishment in the Rat Rats | 1976 | Experimental study | |
| Dihydrobenzofuran Analogues of Hallucinogens. 3. Models of 4-Substituted (2,5-Dimethoxyphenyl)alkylamine Derivatives with Rigidified Methoxy Groups Rats (trained to discriminate saline from LSD tartrate) and rat cortical and... | 1996 | In vivo drug discrimination assay and in vitro radioligand binding assay |