Comparison of stimulants and hallucinogens on shuttle avoidance in rats.
W M Davis, H T Hatoum
General pharmacology 1987 DOI: 10.1016/0306-3623(87)90237-0 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preclinical animal study Peer reviewed |
|---|---|
| Population | Rats trained to a high level of performance of a conditioned avoidance response in a shuttlebox |
| Interventions | mescaline 3 stimulants |
| Key points | The biphasic pattern of mescaline's effects on shuttlebox avoidance was replicated and extended to 12 other hallucinogens of both phenylethylamine and indolealkylamine classes. Hallucinogen response patterns could be differentiated from those of three stimulants and from a methoxyamphetamine compound lacking hallucinogenic activity. |
Abstract
Rats were trained to a high level of performance of a conditioned avoidance response in a shuttlebox to test effects of several classical stimulants in comparison to a variety of hallucinogens. A previously-reported biphasic pattern of effects of mescaline on shuttle avoidance was replicated and extended to 12 other hallucinogens of both phenylethylamine and indolealkylamine classes. Response patterns of hallucinogens could be differentiated from 3 stimulants and from a methoxyamphetamine compound that lacks hallucinogenic activity.
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Cites 4
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