The stimulus properties of para-methoxyamphetamine: a nonessential serotonergic component.
Pharmacology, Biochemistry, and Behavior February 1984 DOI: 10.1016/0091-3057(84)90242-9 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Sample size | 16 |
| Population | Rats (six trained with PMA and saline, ten trained with LSD and saline) |
| Interventions | Pizotyline Saline |
| Dose | PMA 3 mg/kg; LSD 0.1 mg/kg |
| Topics | Serotonin |
| Key findings | PMA established stimulus control in all six rats, with a mean of 19 sessions to criterion (SE = 2, range 14-24). LSD produced intermediate responding in PMA-trained rats, and PMA produced intermediate responding in LSD-trained rats. Pizotyline did not antagonize PMA-induced stimulus control in PMA-trained rats but did antagonize PMA's intermediate responding in LSD-trained subjects. The authors conclude that PMA-induced stimulus control does not depend on serotonergic receptor activation, but that PMA has some LSD-like effects that are serotonergically mediated. |
Abstract
A group of six rats was trained to discriminate the effects of para-methoxyamphetamine (PMA; 3 mg/kg, 15 min pretreatment time) and saline in a two-lever choice task using a fixed ratio 10 schedule of water reinforcement. Stimulus control was assumed to be present when 80% or more of the first ten responses were appropriate for the treatment condition on each of five consecutive days. PMA established stimulus control in each of the subjects. The mean number of sessions prior to the onset of criterion performance was 19 (SE = 2, range = 14-24). A second group of ten rats was similarly trained with lysergic acid diethylamide (LSD; 0.1 mg/kg, 15 min pretreatment time) and saline. In rats trained with PMA, LSD yielded intermediate results, i.e., significantly different from both training conditions. Likewise, the response distribution was intermediate in nature when LSD-trained subjects were tested with PMA. Pizotyline did not antagonize PMA-induced stimulus control in rats trained with PMA and saline but did antagonize the intermediate responding produced by PMA in LSD-trained subjects. It is concluded that PMA-induced stimulus control does not depend upon activation of serotonergic receptors but that PMA does possess some LSD-like effects which are mediated serotonergically.
Comparable studies
Other preclinical and animal studies on serotonin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo Mice | 2021 | Observational cohort | |
| Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. Rats (implied by typical neurochemical study context) | 1987 | Experimental study | |
| Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors In vitro and in vivo (rodent) models | 2023 | Experimental study | |
| 3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. Rat brain | 1987 | Animal experiment | |
| Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs Human and mouse dopamine, norepinephrine, and serotonin transporters expressed in cells | 2006 | In vitro laboratory study |
Citations in the library
Cited by 10
- The paradox of 5-methoxy-N,N-dimethyltryptamine: an indoleamine hallucinogen that induces stimulus control via 5-HT1A receptors. Pharmacology, Biochemistry, and Behavior 2000
- Psilocybin-induced stimulus control in the rat. Pharmacology, Biochemistry, and Behavior October 1, 2007
- Behavioral and biochemical evidence for a nonessential 5-HT2A component of the ibogaine-induced discriminative stimulus. Pharmacology, Biochemistry, and Behavior February 1, 1998
- Stimulus effects of ibogaine in rats trained with yohimbine, DOM, or LSD. Pharmacology, Biochemistry, and Behavior December 1, 1992
- Drug discrimination studies with ibogaine. The Alkaloids: Chemistry and Biology 2001
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